Cellvizio
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CONFOCAL LASER ENDOMICROSCOPY (CLE) Cellvizio Cellvizio GI Brochure INT © Mauna Kea Technologies, May 2016, v1.01 provides real-time vision at the cellular level HD White Light Endoscopy X 30 MACROSCOPIC ANALYSIS Histology BIOPSY: MICROSCOPIC ANALYSIS Cellvizio MINIPROBE

PANCREATIC CYSTS Over 50% of cysts are missing cytological confirmation1 1 out of 5 cysts remains indeterminate after EUS1 Cytology misses half of the mucinous cysts, and CEA levels overlap yielding unspecific result1 4 out of 10 patients with benign pancreatic cysts undergo unnecessary surgery due to uncertain diagnoses2 Repeat EUS-FNA procedures are required ADDING nCLE TO STANDARD PRACTICE CAN HELP: º Improve characterization for indeterminate cysts3-5 º Confirm the EUS impression, when cytological confirmation is missing3-5 Clinical studies have shown that nCLE provides on-the-spot...

BILIARY STRICTURES 60%+ Over 60% of patients remain histologically indeterminate after ERCP6 CONSEQUENCE © Up to 3 ERCP procedures may be required to obtain a diagnosis7 © 15-24% of surgical resections for suspected biliary malignancy reveal benign etiologies8,9 15-24% benign etiology after surgery O Rule out cancer with more confidence for strictures that appear benign6 O Document a malignant ERCP impression, when tissue sampling comes back indeterminate1 Clinical studies have shown that pCLE reduces the number of patients with indeterminate strictures after ERCP1 82% NPV of ERCP with...

BARRETT'S ESOPHAGUS 6% Inefficient random sampling with a low diagnostic yield at 6%15 ? ■ Limited insight on the choice of treatment modality and on the completeness of treatment CONSEQUENCE © Increased patient anxiety & procedural costs © Treatment delay © Recurrence and residual dysplasia Clinical studies have shown that pCLE increases the diagnostic yield of procedures Biopsies can be avoided for 60% of patients18 (When WLE, NBI and pCLE all look normal) Intestinal metaplasia 76% Sensitivity of pCLE with WLE or NBI DONT BIOPCE study, 101 patients, multi-centric16 GastroFlex™ UHD...

Drugs prescription and dosage 25% of patients with colorectal lesions show residual or recurring neoplasia at follow-up post EMR11 Drugs for inflammatory bowel diseases are prescribed and escalated based on symptoms only but the dosage is hard to adapt on symptoms alone13 Patients must await results of follow-up biopsies before potentially returning for additional EMR if needed Increased medication, pain and anxiety for the patient ADDING pCLE TO STANDARD PRACTICE CAN HELP: º Assess in real-time the extent of a flat lesion, allowing immediate and complete endoscopic resection in a single...

CELLVIZIO WORLDWIDE in more than forty countries 800+ Peer reviewed publications on endomicroscopy Cellvizio® Academy Cellvizio® in Gastroenterology Barrett's esophagus Bilio-pancreatic strictures Pancreatic cysts O A dedicated training website: cellvizio.net You have chosen Pancreatic cysts Colorectal lesions O Educational events around the world, led by endomicroscopy experts NORTH AMERICA ASIA Mauna Kea Technologies, Inc. Mauna Kea Technologies China 185 Alewife Brook Parkway, Suite 215 Office 30, 26F, Tengfei Plaza Cambridge, MA 02138, No. 333 Tianyaoqiao Rd, Tel : +1 (678) 731...