The CardioExcyte® 96. Bump up your safety screening - 6 Pages

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Catalogue excerpts

The CardioExcyte® 96. Bump up your safety screening. Smart tools for ion channel research CardioExcyte® 96 Specifications: supported recording modes: impedance-, electric field potential (MEA-like) recordings impedance resolution & bandwith: signal resolution: parallel recording channels: temperature sensing: integrated recording plate sensor validated induced human pluripotent stem cells: ‘CardioExcyte® 96 is an easy-to-use system, providing impedancebased and MEA-like cardiac safety data from a diversity of stem cellderived cardiomyocytes, and constitutes an excellent complement to automated patch clamp-based safety screening. Concentration- and time-dependence of a compound’s potential cardiotoxicity can efficiently be obtained where the alteration of beating patterns can give a hint on what cardiac ion channel is affected, which is where detailed electrophysiology investigations take on the investigations. Cardiac network responses offer a comprehensive view of a compound’s safety profile, without having to use in-vivo methods, which saves time, costs and suffering. Further on, the powerful software, used for recordings and analysis, employs comprehensive beat investigation algorithms, displaying detailed beating kinetics in real-time. Data handling and export is straightforward, easy to grasp and yet very, very powerful.’ Cor.4U®, iCell®, Cellartis hiPS-CMTM, ReproCardio 2, Pluricyte validated human embryonic stems cells: hES-CMCTM, CytivaTM validated murine embryonic stem cells: Cor.At® automated liquid handling available upon request Efficient and reliable cardiotoxicity profiling Inpedance measurements Experiment timecourse Dr. Ralf Kettenhofen, Head of Laboratory, Axiogenesis, Cologne, Germany. The CardioExcyte® 96 bridges the gap between in vivo cardiotoxicity Data Analysis compound sceening by offering relevant means for in vitro recordings from intact, synchronously beating networks of cardiomyocytes. Altered beating patterns give an indication of what ion channel is affected, which can be then followed up by patch clamp-based screening. In this way, the CardioExcyte® 96 is an excellent comFormation of a stable monolayer Begin of spontaneous contractions Time Start of experiment plementary device to automated patch clamp offering new strategies for efficient and reliable saftey and cardiotoxicity screening. Ask us today how the CardioExcyte® 96 can take your cardiotoxicity screening projects to the next level! Combining impedance and MEA-like recordings 6, Adyar Bridge road Kangnam-gu, Seoul Haidian District, Beijing, 100085 China recorded from an autonomously beating cardiac preparation. Room 337, Building 6, Yard No.1 Haidian District, Beijing, 100085 China Manual overlay of impedance (upper trace) and EFP trace data Nanion Technologies GmbH 517-18 Kyungbin Bldg. 4F, Dogok-dong Nanion Technologies China Quantum Design Korea Room 337, Building 6, Yard No.1 where the parameters display the same behavior, but Nanion Technologies China logical and electrical activity of the cardiac cells, vitro cardiac safety assessment. impedance) confer a correlation between the morpho- approach increases the significance and quality of in Bronjo Medi field potential duration (FPD, EFP) and pulse width (PW, different aspects of cardiac repolarization. The hybrid Medi Analytika India Pvt. Ltd the same recording well. Analysis parameters such as access to high resolution impedance and EFP data from The CardioExcyte® 96 is the only system providing Nanion Technologies

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CardioExcyte® 96 Label-free cardiac safety sceening DataControl 96 Software Package. Versatile data analysis & data handling. • 96 recording wells in parallel • Real-time access to beating parameters • Impedance & MEA-like recordings • Climate control • Non-invasive & label-free measurements The CardioExcyte® 96 control software supports online The DataControl96 software package is an indepen- analysis of beating parameters. The unique Mean dent software package to load and analyze data Beat Function automatically visualizes the average of recorded on the CardioExcyte® 96. The analysis • Cost...

 Open the catalogue to page 2

The CardioExcyte® 96. Bump up your safety screening. Smart tools for ion channel research CardioExcyte® 96 Specifications: supported recording modes: impedance-, electric field potential (MEA-like) recordings impedance resolution & bandwith: signal resolution: parallel recording channels: temperature sensing: integrated recording plate sensor validated induced human pluripotent stem cells: ‘CardioExcyte® 96 is an easy-to-use system, providing impedancebased and MEA-like cardiac safety data from a diversity of stem cellderived cardiomyocytes, and constitutes an excellent complement to automated...

 Open the catalogue to page 3

CardioExcyte® 96 Label-free cardiac safety sceening DataControl 96 Software Package. Versatile data analysis & data handling. • 96 recording wells in parallel • Real-time access to beating parameters • Impedance & MEA-like recordings • Climate control • Non-invasive & label-free measurements The CardioExcyte® 96 control software supports online The DataControl96 software package is an indepen- analysis of beating parameters. The unique Mean dent software package to load and analyze data Beat Function automatically visualizes the average of recorded on the CardioExcyte® 96. The analysis • Cost...

 Open the catalogue to page 4

CardioExcyte® 96 Label-free cardiac safety sceening DataControl 96 Software Package. Versatile data analysis & data handling. • 96 recording wells in parallel • Real-time access to beating parameters • Impedance & MEA-like recordings • Climate control • Non-invasive & label-free measurements The CardioExcyte® 96 control software supports online The DataControl96 software package is an indepen- analysis of beating parameters. The unique Mean dent software package to load and analyze data Beat Function automatically visualizes the average of recorded on the CardioExcyte® 96. The analysis • Cost...

 Open the catalogue to page 5

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