Cytogenetics - 8 Pages

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Catalogue excerpts

CY TO GENETICS Your expert around cell culture Prenatal Diagnostic Products Postnatal Diagnostic Products Additional Cytogenetic Reagents

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Prenatal Diagnostic Products    page    4 Postnatal Diagnostic Products    page    5 Additional Cytogenetic Reagents    page    6

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Introduction Cytogenetics Cytogenetics is a ield of study which analyzes the number and structure of human and animal chromosomes. Changes that afect the number and/or structure of the chromosomes can cause problems with growth, development, and how the body functions. he method of cytogenetics is called Karyotyping. It is used to detect chromosomal abnormalities in unborn, in newborn and even adult humans. he basic principle of the method is the preparation of chromosomes for microscopic observation by arresting cell mitosis at metaphase with colchicine and treating the cells with a hypotonic...

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Prenatal diagnostic requires and crucially depends on various invasive and non-invasive techniques in order to examine the fetal nesting and to determine possible fetal genetic abnormalities or malfunctions. Amniocentesis and chorionic biopsy represent essential methods for the invasive diagnostic within the scope of a clinical examination of chromosome abnormalities of a fetus in order to assess the risk of genetic disorders. Why Amniocentesis? Amniocentesis was established in the 1960s and has since then become a common procedure in the cytogenetic routine; cells cultured from these samples...

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POSTNATAL DIAGNOSTICS (LYMPHOCYTES & TUMOR CYTOGENETICS) Postnatal diagnostics he cytogenetic analysis of peripheral blood and bone marrow nowadays forms part of the standard tests performed to diagnose malignant hematological diseases. Cytogenetic analysis includes classical chromosome analysis together with fluorescence in situ hybridization (FISH). Cytogenetic analysis makes an important contribution to the confirmation and specification of a tentative diagnosis, prognosis assessment, therapy options and control of disease progression. Moreover, the identification of specific genetic markers...

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Trypsin solutions are used to release adherent cells from culture surfaces. hey are usually composed of variable concentrations of natural trypsin and EDTA. he concentration of trypsin neccessary to dislodge cells from the substrate depends on different factors such as cell type or age of the culture.

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CYTOGENETICS OVERVIEW

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PAN-Biotech GmbH Am Gewerbepark 13 D-94501 Aidenbach GERMANY Phone: +49 (0)8543/6016-30 Fax: +49 (0)8543/6016-49 www.pan-biotech.com

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