Biochip Array Technology explained - 12 Pages

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Catalogue excerpts

Biochip Array Technology explained The 'Gold Standard' in multiplex testing

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Biochip Background Established in 1982, Randox is a market leader in the field of high quality diagnostic solutions. With origins in clinical chemistry, Randox adapted its expertise and product range to include immunoassays, quality management and life science solutions. Randox’s vision is to develop innovative and clinically meaningful diagnostics, ultimately improving laboratory testing and healthcare solutions worldwide. Approximately 2% of all healthcare costs are diagnostics; however, 70-80% of all clinical decisions are based on the results of diagnostic tests. Traditionally six or seven...

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Put simply, Biochip Array Technology is a multi-analyte testing platform allowing the simultaneous quantitative or qualitative detection of a wide range of analytes from a single sample. It provides a unique platform for assessment of biological samples in a rapid, accurate and easy to use format. The problem with traditional diagnosis Traditional diagnosis takes the form of single analyte assays, even though several tests are usually required. This may result in multiple patient blood draws, increased reagent volume, ultimately increasing time to diagnosis. The solution In response, Randox created...

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Biochip sheets ready for spotting Formatting equipment delivers the droplets of antibody A camera takes an image of every biochip QUALITY CONTROL Many years of development and the exper tise of highly qualified scientists have gone into the creation of the Biochip. We have integrated various different innovative technologies into the biochip production process. Some of which include: Quality is a top priority at Randox throughout our entire product range. The process of ensuring high standards begins at the research stage and is continued into manufacturing, therefore producing a final product...

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ASSAY FORMATS Protein / Antibody assay formats Competitive immunoassay In a competitive immunoassay, the more analyte present in a sample, the less labelled conjugate that will bind to the immunoreaction site. Therefore the signal produced will be low. If there is little analyte in the sample, more labelled conjugate will bind to the capture antibody resulting in a higher signal. Sandwich immunoassay In a sandwich immunoassay, the more analyte present in a sample, the more conjugate will bind to the capture antibody. As a result, the signal will be high. Conversely, lower signal is produced when...

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The biochip detection system is based on a chemiluminescent signal. This is the emission of light, without heat, as a result of a chemical reaction. An enzyme is used to catalyse the chemical reaction on the biochip which generates the chemiluminescent signal. The light emitted from the chemiluminescent reaction that takes place in each DTR is simultaneously detected and quantified using a Charge - Coupled Device (CCD) Camera. This CCD Camera simultaneously records the light emission from all the discrete test sites on each biochip on the biochip carrier. Analysis process on biochip systems 2....

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Key Features and Benefits Highly accurate testing • BAT has a proven high standard of accurate test results with CV’s <10% • Multiplex analysis minimises analytical variation between tests Better patient diagnosis • Testing for multiple markers simultaneously increases the amount of patient information rapidly available to the clinician, allowing for more informed patient diagnosis Optimum efficiency • M ulti-analyte reagents and quality control material, provides highly efficient testing while eliminating any wastage Small sample volume • Reduced sample volume requirements puts the patient at...

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Biochip Test Menu Clinical Arrays Cardiac Array Creatine-Kinase Muscle Brain (CK-MB) Heart Type Fatty Acid Binding Protein (H-FABP) Myoglobin(Myo) Troponin I (cTnI) Thyroid Total Array Thyroid Stimulating Hormone (TSH) Total Thyroxine (TT4) Total Tri-iodothyronine (TT3) Fertility Hormone Array Estradiol (EST) Follicle Stimulating Hormone (FSH) Luteinising Hormone (LH) Progesterone (PROG) Prolactin (PRL) Testosterone (TEST) Vitamin D Array* Vitamin D (VITD) Thyroid Free Array Free Thyroxine (FT4) Free Tri-iodothyronine (FT3) Thyroid Stimulating Hormone (TSH) Tumour PSA Array Carcinoembryonic Antigen...

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Biochip Test Menu Toxicology Arrays Drugs of Abuse Array I Plus Amphetamine Barbiturates Benzodiazepine 1 Benzodiazepine 2 Buprenorphine Cannabinoids Cocaine metabolite (Benzoylecgonine) MDMA Methadone Methamphetamine Opiates Phencyclidine Tricyclic Antidepressants (TCAs Generic) Drugs of Abuse Array III Chloral Hydrate Metabolite Ethyl Glucuronide Fentanyl Ketamine Metabolite Meperidine Meprobamate Zaleplon Zolpidem Zopiclone Flunitrazepam Drugs of Abuse Array IV Acetaminophen Dextromethorphan Escitalopram Drugs of Abuse Array II Buprenorphine Ethyl Glucuronide Fentanyl Fluoxetine Generic Opioids...

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Biochip Test Platforms Fully automated, floor standing Random Access Ideal for STAT samples Multiple tests from 7µl sample Sample matrices include plasma, serum, whole blood Capacity for 200 biochips onboard Barcode scanner for sample traceability Bar-coded samples and RF1D-tagged reagents Applicable for all standard collection tubes Robust Bio-drive robotics Integrated Graphical User Interface Automatic software update via internet Probe liquid level, clot and bubble detection Real time data filtering and reporting User-defined cut-off levels without recalibration Extensive QC data generation Touch...

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Biochip Test Platforms Fully automated, floor standing Multiple tests from 7µl sample Barcode scanner for sample traceability Bar-coded samples and reagents Internal back-up stores over 6 years of results User-defined cut-off levels without recalibration Extensive QC data generation Retrospective reporting Automatic disposal of biochips Chain of custody features Suitable for high throughput laboratories Onboard refrigeration of reagents Semi-automated, bench-top Multiple tests from 25µl sample Ability to store and retrieve work lists saving time Barcode scanner for sample traceability Bar-coded...

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