Familial Hypercholesterolemia (FH) Array - 4 Pages

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Catalogue excerpts

MOLECULAR DIAGNOSTICS Familial Hypercholesterolemia (FH) Arrays Rapid and reliable genetic assessment of patients with suspected FH

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Familial Hypercholesterolemia (FH) Arrays I & II Rapid, simultaneous detection of 40 mutations within the LDLR, ApoB and PCSK9 genes Introduction Familial Hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism. It is a common autosomal dominant, or inherited, disease which affects the plasma clearance of LDL-cholesterol (LDL-C), resulting in premature onset of cardiovascular disease (CVD) and a higher mortality risk.1-3 FH Array I Analyte Name Analyte Name Common genetic defects in FH are mutations in three genes encoding proteins involved in the uptake of LDL-C from the plasma:...

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Principle of the Familial Hypercholesterolemia (FH) Arrays I & II The Randox Familial Hypercholesterolemia Arrays I & II are based on a combination of multiplex PCR and biochip array hybridisation. Innovative PCR priming technology permits high discrimination between multiple wildtype and mutant DNA regions in a number of genes. A unique primer set is designed for each mutation target, which will hybridise to a complementary discrete test region (DTR) on the Randox proprietary biochip array. This combination of Randox priming and spatially organised biochip array technology enables high multiplexing...

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Evidence Investigator Multiplexing...proven, perfected, evolved The Evidence Investigator is a semi-automated, benchtop biochip analyser which offers complete patient profiling. Save time and costs Multiplexing reduces time, labour and reagents associated with multiple individual tests Increase throughput For greater laboratory efficiency Consolidation Of immunoassays and molecular diagnostics, improving laboratory efficiency Result traceability Chain of custody features and bar coded reagents No hidden costs Package includes imaging module, PC and imaging software, thermoshaker, biochip carrier...

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