LT253 Molecular Diagnostics FEB15 - 20 Pages

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Catalogue excerpts

Molecular Diagnostics Precise diagnostics for targeted therapy

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Introduction Randox Biosciences, part of Randox Laboratories, is dedicated to improving health worldwide through scientific discovery, drug development and diagnostics. Spanning four key divisions; Life Sciences, Pharma Sciences, Research and Molecular; Randox Biosciences offers complete tailored solutions for clinical and research use. From initial cultivation of raw materials for assay development, through to providing companion diagnostics, custom and molecular based assays across a range of therapy areas; Randox Biosciences is a trusted partner supplying quality diagnostic solutions to the...

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SNP Genotyping Cardiovascular Risk Prediction Array Rapid multiplex SNP genotyping is based on innovative primer design that can discriminate DNA sequences which differ only at one base. Products amplified will correspond to target por tions of DNA from tissue, buccal swabs or blood. Amplified regions are then hybridised to a biochip array with spatially tethered probes complementary to target amplicons. Each position on the biochip array corresponds to a specific SNP genotype and is capable of both multiplexing and determining the zygosity of the sample. Pathogen Detection STI Multiplex Array...

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Molecular Testing with Evidence Investigator Rapid, accurate and comprehensive molecular testing The Evidence Investigator offers complete patient profiling with the most comprehensive test menu on the market. The Evidence Investigator is a compact, semi-automated bench top platform, consolidating immunoassay and molecular diagnostics on a single platform with protein and DNA biochips. Utilising revolutionary Biochip Array Technology (BAT), the Evidence Investigator allows simultaneous detection of multiple analytes from a single sample for efficient and cost-effective testing.

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Ready-to-use, nine biochip carrier Randox biochips can support multiple assays per biochip Minimum batch of three biochips (one strip) which includes patient sample, positive and negative controls actual size Extract DNA Genomic DNA is extracted from patient sample Amplification Single tube multiplex PCR reaction Hybridisation / conjugation Batches of 3 to 54 biochips are placed in the thermoshaker Wash step and addition of signal reagent After washing, signal reagent is added to each biochip before imaging Biochip carrier loaded into Evidence Investigator A Charged Coupled Device (CCD) camera...

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STI Multiplex Array Rapid, simultaneous detection of 10 common sexually transmitted infections Introduction STIs and related complications, such as infertility or reproductive health problems, represent a significant public health issue in both developed and developing countries. Many infections are asymptomatic and can remain undiagnosed, increasing the risk of unhindered spread. If untreated, STIs can impact fertility, increase risk of ectopic pregnancies and infant mortality. According to the World Health Organisation, more than 1 million people acquire a sexually transmitted infection (STI)...

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The STI Multiplex Array detects 10 STIs in one sample Mycoplasma genitalium (MG) Herpes simplex Virus 1 (HSV-1) Herpes simplex Virus 2 (HSV-2) STI Multiplex Array protocol Extraction Genomic DNA is extracted from urine or urogenital swab samples Single tube multiplex PCR reaction Amplicon hybridisation/ conjugation to biochip array results processing by Evidence Investigator analyser Benefits of the Randox STI Multiplex Array Product features • Rapid turnaround time of ~6 hours from extracted genomic DNA to result • Compatible with various sample matrices including urine and swabs • 54 patient...

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Respiratory Multiplex Array Rapid, simultaneous detection of 22 bacterial and viral pathogens within the upper and lower respiratory tracts Introduction Respiratory tract infections are caused by many viral and bacterial pathogens and are the second most common cause of morbidity and mortality worldwide.1 Acute respiratory disease (ARD) accounts for more than 4 million deaths annually and are the leading cause of death in developing countries.2 Viral respiratory infections can occur in epidemics and can spread rapidly within communities across the globe. Every year, influenza causes respiratory...

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Moraxella catarrhalis Streptococcus pneumoniae Respiratory Multiplex Array Respiratory Multiplex Array detects 22 bacterial and viral pathogens Human respiratory syncytial virus A Human respiratory syncytial virus B Staphylococcus aureus Human parainfluenza virus 1 Haemophilus influenza Human parainfluenza virus 2 Legionella pneumophila Human parainfluenza virus 3 Chlamydophila pneumoniae Human parainfluenza virus 4 Mycoplasma pneumoniae Human bocavirus 1/2/3 Human adenovirus A/B/C/D/E Human coronavirus OC43/HKU1 Human rhinovirus A/B Human metapneumovirus Respiratory Multiplex Array protocol Extraction RNA...

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Clinical data Mass gatherings, such as the Hajj increase the likelihood of the spread of infectious diseases. The Kingdom of Saudi Arabia annually hosts over 2 million Muslim pilgrims from around 184 countries during the Hajj pilgrimage, making it one of the largest and most culturally and geographically diverse mass gatherings in the world. Respiratory tract infections (RTIs) are the most common infection transmitted between pilgrims during Hajj, and most pilgrims develop RTIs during their few weeks stay in Makkah and Madinah.The Randox Respiratory Multiplex Array was used to screen for the presence...

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SINCE THEIR DISCOVERY LAST CENTURY, ANTIBIOTICS HAVE severe infections surgical procedures IN RECENT YEARS, SOME PATHOGENS HAVE ACQUIRED RESISTANCE RENDERING THEM INEFFECTIVE Tract Infections) Staphylococcus Streptococcus aureus pneumoniae Patient misuse • Asking GPs to prescribe antibiotics • Obtaining antibiotics without a • Saving antibiotics for future use • Sharing antibiotics with other • Unnecessarily repeating courses of Inappropriate prescribing Antibiotics are ineffective against many RTIs, particularly viral WHAT CAN BE DONE TO PREVENT ANTIMICROBIAL RESISTANCE? RESIST ASKING DESIST...

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