micrOTOF II
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Bruker Daltonics micrOTOF II The Powerful, Flexible Analysis Solution think forward

Accurate, with “sub-ppm” Confidence Being fully furnished with convincing mass accuracy, a high dynamic range and speed of analysis, micrOTOF II is the first choice for: Molecular Formula Verification De novo Formula Generation Multi-Target Screening Biomarker Discovery Intact Protein Analysis Highest flexibility Significance in biomarker profiling The micrOTOF II is the first high resolution TOF-MS which can be used in combination with GC and LC, providing unequalled flexibility with remarkable mass accuracy. Metabolic profiling is a key technology in the study of drug efficacy, toxicology...

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# possible formulae Mass accuracy plus Chemical expertise additional confidence plus SmartFormula sub-ppm confidence Molecular formula generation Mass accuracy, chemical knowledge and SmartFormula™ clearly limit the number of possible formulae in molecular formula generation for confident determination of the elemental composition of a given peak. This invaluable sub-ppm confidence is available for formula determination in pharmaceutical impurity analysis, metabolite identification as well as in pesticide screening, toxicology & doping with SmartFormula: The correct formula has the best...

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A Dynamic Range that is Impressive mass accuracy over intensity More than five orders of magnitude dynamic range Confidence by 3D mass accuracy ma s 1. hrEICs ≤ 2mDa are gene- rated in a single experiment for >200 compounds 2. A stability of <1mDa is achieved over time of experiment Intra-spectra dynamic range The micrOTOF II knows how to impress with excellent stability of mass measurement over a wide dynamic range without tedious recalibration routines – key for screening applications. The micrOTOF II defines stability in all 3 relevant dimensions of dynamic range: With one single...

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• hrEIC Enables Multi-Target Screening Mass accuracy is independant from concentration The mass accuracy is kept absolutely stable despite large concentration changes. Top: EIC of m/z 243; bottom:m/z position is stable at 243.091 Da +/- 0.001 Da. Samples kindly provided by Astra Zeneca. Dynamic Mass Results with high specificity Mass accuracy over a long period, high mass resolution and a wide dynamic range are prerequisites for high resolution Extracted Ion Chromatograms with 2mDa mass window. High mass accuracy with high High resolution matogram (hrEIC) Detect multiple targets within...

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Multiple Interface Options Coupling with LC or GC for widest range of analytes The micrOTOF II is the only TOF mass spectrometer that can be coupled either to LC or to GC using the same, uniquely designed APCI interface. Gone is the need for an expensive dedicated GC-TOF/MS. This option makes the micrOTOF II the ideal tool for labs which occasionally need a GC/TOF-MS for the identification of unknown peaks in a GC chromatogram or for resolving complex mixtures. The APCI source has been designed to optionally add an excimer laser for applications such as PAH analysis or polymer research...

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Analytical Flexibility Interface to all popular LC systems The sophisticated Hystar LC integration software enables micrOTOF II to seamlessly interface with all leading Liquid Chromatography systems including Agilent 1200, Waters Alliance and CapLC, VWR LaChrom and Dionex Ultimate 3000. The high acquisition speed of micrOTOF II also makes ultra-high performance systems such as UPLC ideal partners and this is fully supported by our integration software. Bruker EASY-nLC is the ideal HPCL system for Proteomics applications. Capillary electrophoresis and micrOTOF II Complementing LC methods and...

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Technical Specifications Sophisticated micrOTOF focus technology Worldleading combination of mass accuracy, resolution, and sensitivity SmartFormula is the unique combination of accurate mass with True Isotopic Pattern (TIP) Automated determination of elemental composition, the “formula finder” Footprint 640 x 640 mm, height 1220 mm, weight 130 kg Mass range 50 – 20,000 m/z Mass resolution 16,500 FWHM with micrOTOF focus Mass accuracy of < 1-2 ppm (RMS) error with internal calibration Mass Stability & Dynamic Range proven by better than 2mDa hrEICs (high resolution Extracted Ion...

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