Information for Healthcare Professionals
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Information for Healthcare Professionals

Peripheral artierial disease (PAD) is a medical condition where the blood circulation in the limbs is reduced and leads to pain, chronic wounds and amputations. PAD affects the health and quality of life of an estimated 200m people worldwide and is projected to rise disproportionately in the coming years.1 Risk Factors Smoker or used to smoke The healthcare cost of a PAD patient is 3-4 times higher p.a. compared to the average adult control without PAD. High cholesterol Diabetes Mellitus Health Pain Comorbidity Mortality Amputation Treatment Symptomatic treatment: • Pharmaceutical • Wound...

1 in 5 people over 50 have some degree of PAD.6 It’s more common in men than in women.7 Around 2% of people with intermittent claudication will eventually undergo amputation, making PAD one of the biggest causes of lower-limb amputation.8 Approximately 5000 major amputations are undertaken in England every year, with over 90% being PAD related.9 FlowOx™ - Mode of Action Intermittent Negative Pressure (INP) Translating Acute Effects into Long Term Effect Acute Effect on Blood Flow First 1-3 seconds: Rapid increase of transmural pressure during -40 mmHg phase. Initiation of transient...

The Effect Intermittent negative pressure (INP) stimulates the micro- and macrocirculation of blood in the extremities and when applied regularly, it will revitalise the natural endothelial function - similar to the way muscle strength and function can improve through regular exercise. INP will work even in the smallest blood vessels and thereby can improve function and blood flow to the extremities and skin.4, 5, 10 An unmet medical need... Current treatment strategies for PAD are often limited, inadequate and symptomatic, resulting in poor outcomes. FlowOx™ offers a baseline intervention...

Ordering information For orders, deliveries and general enquires please contact Otivio AS: Tel.: +49 151 28 27 35 36 E-Mail: info@otivio.com References: 1. Medpage Today, August 2, 2013. 2. All-Part Parliamentary Group, 2016. Saving limbs, saving lives: patient access to technologies for the diagnosis and treatment of peripheral arterial disease. 3. Scully, RE., DeBord Smith, A. et al. 2016. Annual Health Care Expenditures in Individuals with Peripheral Arterial Disease, Journal of Vascular Surgery, Vol 64(4), 1180–1181. 4. Sundby Ø. et al., 2017. Blood flow in PAD patients enhanced by...