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CARDIOLOGY & LIPID TESTING COMPLETE CARDIOLOGY & LIPID TESTING FROM RANDOX

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CARDIOLOGY & LIPID TESTING Complete Cardiology and Lipid Testing from Randox

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sdLDL CHOLESTEROL APOLIPOPROTEIN C-III DIAGNOSTIC BIOCHIP PRODUCTS RESEARCH BIOCHIP PRODUCTS ORDERING INFORMATION GLOBAL DIAGNOSTIC SOLUTIONS PROVIDER NP NICHE PRODUCT When you see this symbol you will know that Randox have one of the only automated biochemistry assays available on the market UF UNIQUE FEATURE When you see this symbol you will know that this feature is unique to the Randox product

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BENEFITS OF RANDOX REAGENTS Randox offers an extensive range of third party diagnostic reagents which are internationally recognised as being of the highest quality; producing accurate and precise results. We have a considerable test menu of over 100 assays, covering over 100 disease markers including: antioxidants, diabetes, drugs of abuse testing, lipids, specific proteins, therapeutic drug monitoring and veterinary testing. EXPAND YOUR TEST MENU WITHOUT EXPANDING YOUR LAB There is no need to buy any extra equipment in order to expand your test menu. Our reagents can be programmed onto...

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INTRODUCTION TO RANDOX CARDIOLOGY AND LIPID TESTING International bodies, including the National Lipid Association and the European Guidelines on Cardiovascular Disease (CVD) Prevention in Clinical Practice advocate measuring lipids to truly identify CVD risk. However, the traditional lipid panel of cholesterol, HDL-C, triglycerides and LDL-C only detect approximately 20% of all coronary artery disease (CAD) patients. Advanced lipid testing is recommended to optimise patient treatment, both in primary and secondary risk categories and as such provide the necessary tools to prevent and...

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HDL CHOLESTEROL Clinical Significance Key Features of the Randox HDL Cholesterol Assay UF High-density lipoproteins (HDL) are one of the major classes of plasma lipoproteins. HDL-C is often referred to as ‘good cholesterol’ as it transports from the tissues to the liver for removal from the body. High levels of HDL-C can lower the risk of developing heart disease. Superior direct clearance methodology ensuring truly accurate results even with abnormal samples Liquid ready-to-use reagents for convenience and ease of use Extensive measuring range of 0.189 - 3.73mmol/L Applications available...

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Fig. 3 Specificity of Randox Direct Clearance Assay for HDL Cholesterol Specificity of the Randox direct clearance HDL-C assay was verified against gel filtration. Fig. 3 indicates how specific the Randox direct clearance method is for HDL-C. Our kit was found to only react with the HDL-C fractions separated by gel filtration. Total Cholesterol Reagent 1 Randox HDL Cholesterol Reagent THE DIAGRAM ABOVE SHOWS HOW SPECIFIC THE RANDOX DIRECT CLEARANCE METHOD IS All ordering information can be found on Page 20-2

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LDL CHOLESTEROL Key Features of the Randox LDL Cholesterol Assay • • • • UF Superior direct clearance methodology ensuring truly accurate results are delivered Liquid ready-to-use reagents for convenience and ease-of-use Extensive measuring range of 0.189 – 22.2mmol/L for the measurement of clinically significant levels Applications available detailing instrument-specific settings for the convenient use of the Randox LDL Cholesterol (LDL-C) assay on a wide range of clinical chemistry analysers Benefits of the Randox Direct Clearance Method The Randox direct clearance method eliminates...

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Fig. 5 Specificity of the Randox Direct Clearance Assay for LDL Cholesterol Specificity of the Randox direct clearance LDL-C assay was verified against gel filtration. Fig. 5 indicates how specific the Randox direct clearance method is for LDL-C. Our kit was found to only react with the LDL-C fractions separated by gel filtration. Randox LDL Cholesterol Total Cholesterol 1 THE FRIEDEWALD FORMULA HAS BEEN REPORTED TO MISCLASSIFY UP TO 50% OF PATIENTS3 % of samples misestimated by more than 10% All ordering information can be found on Page 20-2

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TOTAL CHOLESTEROL & TRIGLYCERIDES Triglycerides: recommended levels below Cholesterol: recommended levels below CHOLESTEROL (TOTAL) Key Features of the Randox Cholesterol Assay Key Features of the Randox Triglycerides Assay Wide range of kits available ensuring laboratories of all sizes can find a product to suit their needs Liquid ready-to-use reagents for convenience and ease-of-use Standards included in certain kits for user convenience (these are for manual and semi-automated use only) Extensive measuring range of 0.865-16.6 mmol/L for the measurement of clinically significant levels...

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sdLDL CHOLESTEROL SMALL-DENSE LDL CHOLESTEROL (sdLDL-C) Fig. 6 Correlation of Ultracentrifugation and Denka Seiken Methods. 6 Key Features of the Randox sdLDL Cholesterol Assay Until recently, the primary methods of assessing a patient’s sdLDL-C levels were based on techniques such as ultracentrifugation and electrophoresis both of which are extremely laborious and time-consuming. 4 sdLDL-C can now be assessed in the routine biochemistry laboratory using the Randox Clearance assay. • Randox sdLDL-C utilises the clearance method which produces results in ten minutes. There are two main...

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Criteria to overcome challenges of Lp(a) measurement Traditional challenges of Lp(a) measurement The widespread use of Lp(a) as an independent risk factor for cardiovascular disease risk has, until recently, been impeded by the lack of internationally accepted standardisation and the fact that many commercial Lp(a) methods suffer from apolipoprotein (a) (apo(a)) size related bias, potentially leading to patient misclassification. The size heterogeneity of apo(a) affects, to varying degrees the results of many commercially available Lp(a) kits. This may result in an underestimation of Lp(a)...

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Clinical Significance The determination of Lp(a) levels is intended for use in conjunction with the clinical evaluation, patient risk assessment and other lipid tests to evaluate disorders of lipid metabolism and to assess coronary heart disease in specific populations. The size of the apo(a) protein is genetically determined and varies widely. As such, the levels of Lp(a) can vary up to 1000-fold between individuals.9 Recent years have seen major scientific advances in the understanding of Lp(a) and its causal role in premature cardiovascular disease (CVD). Elevated Lp(a) levels are...

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