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LT250 STI Multiplex Array NOV14

LT250 STI Multiplex Array NOV14
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Rapid, simultaneous detection of 10 sexually transmitted infections

STI Multiplex Array Rapid, simultaneous detection of 10 sexually transmitted infections Introduction The STI Multiplex Array rapidly screens for the presence of 10 different STIs simultaneously from one patient sample. The assay is based on a combination of multiplex PCR, probe to allow screening of viral, bacterial and protozoan STIs. The simultaneous detection of these infections provides a comprehensive profile for each patient, enabling the clinician to decide on the best treatment options, potentially decreasing antibiotic misuse and the risk of the infection spreading. The STI...

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The STI Multiplex Array detects 10 STIs in one sample Neisseria gonorrhoea (NG) Herpes simplex Virus 1 (HSV-1) Chlamydia trachomatis (CT): The number of new cases worldwide of Chlamydia trachomatis in adults aged 15-49 was estimated to be 105.7 million in 2008.1 Due to its possible subclinical nature, chlamydia may remain undiagnosed for years, which increases its rate of transmission. If left undiagnosed and untreated, it can lead to pelvic inflammatory disease (PID)2, which may increase the risk of ectopic pregnancy3 or reduce fertility in both sexes.4 Neisseria gonorrhoea (NG): whilst...

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Why use the STI Multiplex Array? Through the use of simultaneous multiplex testing, smaller sample volumes are required. Instead of limiting the amount of information available, more information can be reported thus ensuring a complete profile of all pathogens present. The STI Multiplex Array provides excellent precision, specificity, sensitivity and accuracy for STI diagnosis, which ultimately results in a reduced risk of false reporting and the number of unnecessary confirmatory tests. By using BAT, spatial separation between assays allows for simple interpretation of results. STI...

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Clinical significance of the STI Multiplex Array STIs and related complications represent a significant public health issue in both developed and developing countries. Many infections are asymptomatic and remain undiagnosed, increasing the risk of unhindered spread. STIs may induce serious complications that reduce fer tility, increase risk of ectopic pregnancies and infant mor tality. Existing technologies or screening programmes do not meet the social or clinical need. Randox has developed this multiplex PCR assay coupled to Biochip Array Technology to provide a rapid, efficient and...

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Performance characteristics Assay Specificity and Sensitivity Assay specificity and sensitivity for each pathogen was determined through testing clinical samples (Table 1) with the exception of HD where reference strains were used. Table 1. Randox STI Multiplex Array sensitivity and specificity data Pathogen True Positive False Positive True Negative False Negative 100* *reference strains were used Clear advantage of multiplexing for STIs using the Randox kit is shown (Table 2), where there is evidence of significant co-infection in clinical samples. Table 2. Rates of co-infection in...

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Gender-specific sensitivity and specificity data summary Table 3 provides evidence of maintained multiplex PCR sensitivity (a) and specificity (b) between gender and across sample matrices. Table 3(a). Sample matrix sensitivity summary Pathogen Female genital swabs Male genital swabs Unclassified swabs Rectal swabs Female genital swabs Male genital swabs Unclassified swabs Rectal swabs Table 3(b). Sample matrix specificity summary Pathogen References 1. orld Health Organisation (2008). Global incidence and prevalence of curable sexually transmitted infections. Available at:...

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Evidence Investigator Multiplexing...proven, perfected, evolved The Evidence Investigator is a semi-automated, benchtop biochip analyser which offers complete patient profiling. Save time and costs Multiplexing reduces time, labour and reagents associated with multiple individual tests Increase throughput For greater laboratory efficiency Consolidation Of immunoassays and molecular diagnostics, improving laboratory efficiency Result traceability Chain of custody features and bar coded reagents No hidden costs Package includes imaging module, PC and imaging software, thermoshaker, biochip...

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