OsteoBiol®
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REGENERATION SCIENCE INSPIRED BY NATURE Bone Grafting Materials

New Putty packaging in syringe Pag. 17 New Curved Cortical Lamina Pag. 24 International Journal of Periodontics and Restorative Dentistry, 2008, 28: 283-289 Clinical Oral Implants Research, 2008, 19: 511-515 International Journal of Periodontics and Restorative Dentistry, 2008, 28:469-477 Clinical Implant Dentistry and Related Research, 2008, 10: 264-270 Journal of Immunopathology and Pharmacology, 2007, 20: 89-93

Origin of OsteoBiol biomaterials Pag. 2 A significant step ahead Pag. 4 Collagen: a key factor for clinical success Pag. 5 Collagen and bone regeneration Pag. 6 From heterologous bone to biomaterial Pag. 8 Product Specifications OsteoBiol fillers composition Pag. 12 Soft Cortical Lamina Pag. 23 Curved Cortical Lamina Pag. 24 Publications and Case Reports Deep infrabony defect Pag. 38 Maxillary sinus lift with crestal access Pag. 39 Bilateral sinus lift Pag. 40 Lateral augmentation: self containing area Pag. 41 Regeneration of peri-implantitis defects Pag. 42 Augmentation beyond the skeletal...

Nature provides all the necessary elements for bone regeneration Our aim is to accelerate and guide this process

A natural bone matrix Detail of a Gen-Os granule: vascular canal entrance with evident centralized osteonic structure. Source: Nobil Bioricerche (Italy) 10 years of scientific research

A significant step ahead Research and development of biomaterials has gone through many stages, but always toward one goal: to heal bone deficit with newly-formed quality tissue in order to achieve functional recovery. All of this in the least time possible. The examination of clinical results and the commercial diffusion of various kinds of products developed by the biomedical industry show a clear superiority of products of natural origin over those of synthetic derivation. The structure of animal bone is morphologically more similar to human bone than any synthesized product. SEM image...

Collagen: a key factor for clinical success COMPOSITION OF GEN-OS Tecnoss exclusive manufacturing process is able to neutralize the antigenic components present in heterologous bone (achievement of biocompatibility) and to preserve the collagen matrix inside biomaterial granules. Moreover, the molecular structure of natural hydroxyapatite is not significantly altered thanks to the limited maximum process temperature. MINERAL BONE (1) - COLLAGEN (2) These characteristics of OsteoBiol products allow a consistent bone neo-formation and a close contact between mature neo-formed bone and...

Collagen and bone regeneration Gui de d bon e r e ge n e r ati on ( GBR ) i s n e c e s s ar y to tr e at bon e de f i c i ts due to l e s i on s or bac te r i al i n f e c ti on s . Graphic representation of collagen triple helix. Th e bon e de f e c t r e c ov e r y oc c ur s th r ough th e ge n e r al m e c h an i s m s of ti s s ue h e al i n g, th at i s , by c om pl e x dyn am i c m e c h an i s m s di r e c te d towar ds th e r e pai r of ti s s ue f un c ti on an d an atom i c i n te gr i ty. Electronic microscopic view of OsteoBiol dried membrane with indication of its thickness...

SUBSTRATE: collagen OSTEOPROGENITOR CELLS: bone marrow GROWTH FACTORS TGFß1 – BMP: blood REGENERATION: alveolar bone periodontal ligament cementum Key elements for tissue and bone regneration (Nakashima N. et al., 2003, modified; 3). SUBSTRATE: TEM image of OsteoBiol Gen-Os granule, in which it is possible to appreciate the collagen fibers. This important scientific evidence provides the rationale behind OsteoBiol product line: a complete series of biomaterials with collagen base. Collagen, in addition to its well-known structural action carried on connective tissues, is endowed with the...

From heterologous bone to biomaterial A biomaterial for the reconstruction of bone defects must be biocompatible and have good handling and mode ling properties; in specific clinical situations, it must also provide sufficient resistance to loading. Te c n os s l abor ator i e s ar e s pe c i al i z e d i n pr oc e s s i n g h e te r ol ogous bon y an d c ol l age n i c ti s s ue s . O s te oBi ol bon e pr oc e s s , i n par ti c ul ar, h as be e n de v e l ope d to m odi f y but m ai n tai n th e or i gi n al c ol l age n m atr i x of h e te r ol o gous ti s s ue , i n or de r to pr e s e...

The basic research for development of OsteoBiol product line has thus been driven by the ideal biomaterial concept: a material with the highest affinity to the new endogenous bone. To pursue this aim, Tecnoss developed a biotechnology, able, by avoiding the high temperature cera-mization phase, to preserve the structure of natural hydroxyapatite and therefore allow an osteoclastic-type remodeling of biomaterial, similar to physiological bone turnover time (1). Thanks to this innovative technology, the OsteoBiol line has the following important characteristics: 1. absence of a foreign body...

Product Specifications

* Approximate percentages in volume subjet to a variability range depending on the heterologous origin of the bony tissue organic component (collagen etc.) cortical bone cancellous bone inorganic component (mineral) heterologous bone composition Collagenated fillers composition

GRANULOMETRY The average reported values are indicative and subject to a variability range depending on the heterologous origin of the products. COMPOSITION The average reported values are indicative and subject to a variability range depending on the composition of the tissues of origin. RE-ENTRY TIME The reported values are estimates and purely indicative: these values can therefore vary depending on the patient and grafting site.

Gen-Os TISSUE OF ORIGIN TISSUE COLLAGEN PHYSICAL FORM GRANULOMETRY RE-ENTRY TIME CATALOG LINKS PACKAGING AND CODES 0373 MIX OF CANCELLOUS AND CORTICAL HETEROLOGOUS BONE PRESERVED GRANULES SLIGHTLY RADIOPAQUE STANDARD 250-1000 µm 4/5 MONTHS DEPENDING FROM GRAFTING SITE CHARACTERISTICS CASE REPORTS PAG. 34 - 36 - 37 - 41 - 42 - 45 BIOCOMPATIBILITY TESTS PAG. 52 - 53 VIAL 0,25 gr. - VIAL 0,5 gr. - VIAL 1,0 gr. - VIAL 2,0 gr. Characteristics: a natural replicate of autologous bone, Gen-Os conserves the same intimate structures (matrix and porous form) and presents a high osteoconductive...