Complement factor-H
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COMPLEMENT FACTOR H ELISA DETECTION OF IgG ANTIBODIES › Autoimmune hemolytic-uremic syndrome diagnostics › Differential diagnostics of hemolytic-uremic syndrome

ANTI-COMPLEMENT FACTOR H ANTIBODIES DETECTION Differential diagnostics › Hemolytic-uremic syndrome › Autoimmune hemolytic-uremic syndrome › DEAP HUS (deficiency of CFHR plasma proteins and factor H autoantibody positive HUS) Factor H is a complement regulatory glycoprotein that is found in human plasma in concentrations about 500 μg/mL. Its main function is the regulation of complement activation. Inhibitory autoantibodies against complement factor H resulting from an immunopathological reaction dysregulate complement system. Such autoimmune dysregulation of complement is associated with a...

COMPLEMENT FACTOR H ELISA DETECTION OF IgG ANTIBODIES Evaluation study The evaluation study of ELISA-VIDITEST anti-complement factor H was performed in The Institute of Hematology and Blood Transfusion (Prague) and VIDIA spol. s r.o. with serum and plasma samples from The Institute of Hematology and Blood Transfusion. Samples: › Negative samples - serum and plasma samples from blood donors: 130 samples › Samples clinically close to HUS: › Acquired thrombotic thrombocytopenic purpura (TPP) (acute stage): 20 samples › Atypical HUS (with CFH or MCP mutation): 8 samples › Inherited TPP: 5...

COMPLEMENT FACTOR H ELISA DETECTION OF IgG ANTIBODIES Advantages > High sensitivity and specificity > Quantitative evaluation > First commercially available anti-complement factor H CE IVD certified kit > I ncubation at laboratory temperature VIDIA spol. s r.o. Nad Safinou II 365 252 50 Vestec Czech Republic EUROPEAN UNION European Regional Development Fund Operational Programme Enterprise and Innovations for Competitiveness