Patch Clamp Amplifier The Model 2400 Patch Clamp Amplifier is a low noise, full featured patch clamp designed for voltage clamping using patch electrodes on single channels or whole cells. Amplifier current gain can be matched to your experimental needs by selecting one of the three available dual resistive feedback probes. Currents with outputs of 10mV/nA to 1mV/fA can be recorded. (See Specifications on the reverse side for details). Unlike other patch clamp amplifiers, the Model 2400 has a voltage follower in the probe. This allows this amplifier to be a true fast current clamp amplifier with no instability. An integrated four pole low pass Bessel filter provides flexible signal conditioning. Fine tuning capacity compensation is available to eliminate virtually all electrode-induced Dual Resistive-Feedback Headstage transients. Calibrated whole cell compensation provide easy display of membrane capacitance and access resistance. A host of command potentials include an automatic tracking command to zero the membrane current, manual controls for offset and holding potentials, and an easily readable digital display. For signals that are more complicated, an external command input with different scaling factors is available for use with any signal source. A digital meter provides accurate values of command signals and membrane currents or voltages, the true RMS noise of the amplifier and experimental setup, the cut off Full-function Patch Clamp for both whole cell and patch recordings True current clamp due to voltage follower in headstage Switchable dual resistive feedback headstage frequency of the low pass filter, and the overall gain of the amplifier plus probe. Series resistance compensation provides the researcher with the option of introducing either or both predictive and corrective compensation from zero to 100%. Fine and coarse controls for lag provide sensitive control to minimize oscillation produced by compensation close to 100%. Separate compensation controls exist for eliminating transients seen during Capacity, series resistance, and whole cell compensation 4-pole low-pass Bessel filters current clamp experiments when the bridge balance is used. Internally generated test signals Telegraph outputs, which provide analog voltage equivalents of amplifier mode, gain, Telegraph outputs for all major front panel controls Cmembrane, RMS noise, and the low pass filter settings, allow your system software to record the Model 2400’s front panel settings during the course of your experiment. The Model 2400 Patch Clamp Amplifier can be your lab’s workhourse amplifier for a fraction of the price of other instruments on the market. Perfect for research or teaching applications. Built-in display for critical values Includes rack mount hardware 3-year warrant

Patch Clamp Amplifier A-M SYSTEMS™ Specifications Probe Gain and Bandwidth Feedback Resistor 10 Megohm 100 Megohm 1 Gigohm 10 Gigohm Probe Gain Maximum Current Noise Voltage clamp modes measured with internal 4 pole Bessel filter: Headstage Resistor (ohms) 10M 100M 1G 10G Current clamp modes have noise levels less than 20pV with inputs shorted. Membrane Current Output Range Probe Feedback Resistor 10 Meg 100 Meg 1 Gig 10 Gig Membrane Voltage Output Range 10mV/mV-1V/mV Filter Capacity Compensation Whole Cell Compensation Series Resistance DC Balance 4 pole Bessel filter: 0.5 kHz, 1.0 kHz, 2.0...