Data Sheet Agilent 6470B Triple Quadrupole LC/MS with Agilent Jet Stream Source The Agilent 6470B triple Quadrupole LC/MS delivers superior reliability, sensitivity, and robustness for targeted trace-level analysis. Designed with robustness, versatility, and throughput in mind, it contains Agilent's signature octopole ion guide, hyperbolic quadrupoles, curved and tapered hexapole collision cell, and advanced detector geometry. Built with VacShield to reduce instrument downtime providing faster maintenance without breaking vacuum. The end result is a rugged and versatile instrument suitable for high-throughput targeted screening or trace-level quantitative research applications. Parameter 10 fg of reserpine injected on column, quantifying on the transition m/z 609.3 to 195.1 IDL <4.0 fg, with 99% confidence (verified onsite during installation) 10 fg of chloramphenicol injected on column, quantifying on the transition m/z 321.0 to 152.0 1 pg of reserpine injected on column, quantifying on the transition m/z 609.3 to 195.1 1 pg of chloramphenicol injected on column, quantifying on the transition m/z 321.0 to 152.0 Mass resolution (autotune) Automatically adjusted during Autotune procedure 0.7 Da, 1.2 Da, and 2.5 Da (Unit, Wide, Widest) Mass resolution (manual tune) Manually adjusted by the user during Manual tune procedure Mass range Mass accuracy 0.1 Da from m/z 5 to 1.000 0.2 Da from m/z 1,000 to 2,000 0.3 Da from m/z 2,000 to 3,000 Mass stability <0.1 Da in 24 hours up to m/z 2,122 in Positive mode and m/z 2,234 in Negative mode Dynamic range >6.0 × 106, resulting in up to 6 orders of linear dynamic range from the LOD Polarity switching (electronics) Acquisition modes MS1 scan, MS2 scan, product ion scan, neutral loss scan, neutral gain scan, precursor ion scan, SIM, and MRM (static, dynamic, triggered) Maximum scan rate Maximum MRM acquisition rate Minimum MRM dwell time 450 per time segment, up to 13,500 ion transitions per method 4,000 dynamic MRM transitions per method Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation Collision cell ion clearance

General system specifications Parameter Single point of control Specification Single-point data system method capability with full control of Agilent Infinity I and Infinity II and Agilent 6470B triple quadrupole LC/MS systems Polarity change in time segment Time programming Dedicated scan modes (Full Scan, Product Ion Scan, Precursor Ion Scan, Neutral Loss Scan, and Neutral Gain Scan) or targeted ion monitoring (SIM, MRM, dMRM, and tMRM) Dynamic and triggered MRM aligns MRMs with compound retention time Solvent divert through calibrant delivery system valve within the analysis Agilent Jet Stream...