Agilent 6495C Triple Quadrupole LC/MS with iFunnel Technology
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Data Sheet Agilent 6495C Triple Quadrupole LC/MS with iFunnel Technology Born out of our drive for innovation, Agilent’s 6495C triple quadrupole LC/MS is a powerful and reliable mass spectrometer for applications demanding the lowest limits of detection and highest reproducibility. To maintain high sensitivity for confident results, the 6495C features Agilent’s signature octopole ion guide, hyperbolic quadrupoles, curved and tapered collision cell, and advanced detector geometry. The inclusion of a hexabore capillary paired with a third-generation iFunnel greatly enhances signal while reducing noise. VacShield reduces instrument downtime by enabling easier and faster maintenance without breaking vacuum. By combining sensitivity and robustness in a high-performance mass spectrometer, you can be confident in your results with the 6495C triple quadrupole LC/MS. Parameter 1 fg of reserpine injected on column, quantifying on the transition m/z 609.3 to 195.1 IDL<0.6 fg, with 99% confidence (verified onsite during installation) 1 fg of chloramphenicol injected on column, quantifying on the transition m/z 321.0 to 152.0 1 pg of reserpine injected on column, quantifying on the transition m/z 609.3 to 195.1 1 pg of chloramphenicol injected on column, quantifying on the transition m/z 321.0 to 152.0 Mass Range Polarity Switching (Electronics) Mass Resolution (Autotune) Full width at half maximum Mass Resolution (Manual Tune) Full width at half maximum Mass Accuracy 0.1 Da from m/z 5 to 1.000 0.2 Da from m/z 1,000 to 2,000 0.3 Da from m/z 2,000 to 3,000 Mass Stability <0.1 Da in 24 hours up to m/z 2,122 in Positive mode and m/z 2,234 in Negative mode Dynamic Range >6.0 × 106, resulting in up to 6 orders of linear dynamic range from the LOD Acquisition and Scan Modes MS1 scan, MS2 scan, product ion scan, neutral loss scan, neutral gain scan, precursor ion scan, SIM, and MRM (static, dynamic, triggered) Maximum Scan Rate Maximum MRM Acquisition Rate Minimum MRM Dwell Time 450 per time segment, up to 13,500 ion transitions per method 4,000 dynamic MRM transitions per method Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation Collision Cell Ion Clearance

General system specifications Parameter Single Point of Control Single-point data system method capability with full control of Agilent Infinity I and Infinity II and Agilent 6470B triple quadrupole LC/MS systems Time Programming Polarity change in time segment Scan and SIM or MRM (plus other modes of data collection) Dynamic and triggered MRM aligns MRMs with compound retention time Solvent divert through calibrant delivery system valve Wide Range of Ionization Sources Agilent Jet Stream (AJS) Technology Electrospray (ESI) Nanospray ESI (nESI) source APCI source (Atmospheric Pressure...