Activotec Activo-Darwin Peptide Synthesizer The Activo-Darwin Peptide Synthesizer is an economical semi-automated instrument for the synthesis of very high quality peptides. • High quality peptides • Any scale from 0.05 mmole to 20.0 mmoles • Easy to use; use existing or define your own protocols • Automates the resin washing and deprotection steps of synthesis • Performs any Fmoc or t-Boc chemistries • Green chemistry compatible • Automated optional reactor heating to 90°C • Safe to use, instrument is totally enclosed • Disposable reactors • Use commercially available resins and reagents High Quality Peptide • Inert atmosphere throughout • Precise and fast solvent delivery and washing • Efficient inversion mixing Ease of Use • Very easy to use touch screen display • Enter the sequence, fill in quantity and resin and press run • Software generated worksheet tells the user what to prepare • Free choice of chemistry, present and future • Logfile of each synthesis • Easy cleave system direct from the disposable reactor • Email notifications

Chemistry • Fmoc or t-Boc • Green chemistries • Coupling reagents HBTU, HCTU, HATU, TBTU, PyBOP, DIC, COMU, etc • Synthesize any length peptides Chemistry Fmoc or t-Boc Activation method Pre-activation or in situ, user selectable. HATU, HBTU, HCTU, DIC, PyBOP, etc Reaction vessel sizes 10 mL, 40 mL, 125 mL, 250 mL, 500 mL Reagent/solvent bottles 3 as standard, range from 250 mL to 19 litres, 4th optional Reactor heating Ambient to + 90° C Mixing system Over centre mixing with variable speed and amplitude, nitrogen bubbling Inert atmosphere 100% throughout the system Fluid measurement Timed delivery...