ADALTIS MOLECULAR DIAGNOSTICS Advanced Automation in Molecular Biology EXTRAlab Fully-automated Molecular Diagnostics instrument for clinical diagnostics A workstation for high quality Nucleic Acid isolation ■ Nucleic Acids DNA / RNA Extraction PCR Purification PCR/qPCR Set-Up NGS Library Preparation

ADALTIS MOLECULAR DIAGNOSTICS

SAMPLE PROCESSING, NUCLEIC ACID EXTRACTION AND DOWNSTREAM ANALYSIS IN ONE STEP MAIN FEATURES & BENEFITS Modular design - additional devices can be integrated User-friendly software Samples and reagents traceability with bar-code reader Wide range of customisable protocols Reagent rack with autonomy up to 48 samples Quick programming of every applicable protocol Time for the extraction: 48 samples - 118 minutes, PCR set-up - 22 minutes Easy protocol selection from libraries Elution volume: from 40µl to 200µl Remote monitoring of activities Possibility to use different protocols with auto-sampling,...

Simple and comprehensive NGS workflow designed to process the sample through sequencing with minimal time and effort. Automated Preparation protocols reducing the time and possibility of user error compared to a more “traditional” library preparation protocol. LIBRARY PREPARATION PROTOCOL n MasterMix Up to 16 Patient Samples qPCR plate or PCR tubes Oligo Mix Primers, Indexes 1-96 (PCR Plate) CSV file The CSV file contains the coordinates of the index plate The generated CSV file contains the coordinates of the index plate taken from each sample SAMPLE NORMALISATION AND LIBRARY POOLING BEAD PURIFICATION...

TECHNICAL SPECIFICATIONS Multifunction robotic arm Liquid handling tool 2mL deepwell for lysis and elution Magnetic tool with 24 parallel magnetic rods, suitable for all magnetic beads 2mL deepwell for magnetic bead washing Primary tubes 16mm + 13mm + Eppendorf EASY & INTUITIVE PROTOCOL GRAPHIC EDITOR Conductive tips with filter (50µL, 200µL, 1000µL) Magnetic rod covers for bead transfer Dispensing system Pipetting via disposable conductive tips (with filters) Capacitive liquid level sensing system Control system Internal control system and remote monitoring through HMI software PC and integrated...

Molecular diagnostic panels and reagent kits for nucleic acid extraction and RT-PCR of infectious diseases and genomics The Diagnostic kits of MOLgen series were developed for detection, confirmation and genotyping of infectious and genetics diseases by Real-Time PCR. The proprietary development enable us to provide you with a standardised, simple and readily reproducible procedure. Standardised and easy approach to PCR Diagnostics We provide convenient solutions in reagent configuration such as lyophilised, ready-to-use mixtures with a long shelf-life and the possibility to ship the kits at...

EXTRAlab Results High yield , purity and integrity of the nucleic acid extract Starting Matrix Blood/saliva (200 pl) Liver (15mg) Lung (15mg) Brain (15mg) Kidney (15mg) FFPE Brain (3 sect. da 5pm) Yield Average Purity Average

Customer Care Center e-mail: [email protected] Order handling and Logistics e-mail: [email protected] Technical Assistance e-mail: [email protected] MDx Technical Assistance e-mail: [email protected] MDx Application Assistance e-mail: [email protected] Legal Registered Office Via Durini, 27 20122 Milano, Italy Tel: + 39 0774 5791 Fax. + 39 0774 353085 Adaltis S.r.l. Headquarter Production and Development Plant Via Luigi Einaudi 7 Guidonia di Montecelio 00012 Rome, Italy ADALTIS is certified in compliance with ISO9001 and ISO 13485. Our products are CE-IVD. © EXTRAlab NGS Prep 1 1. 2023 V3.0...