CellWriterTM S FEATURES AND BENEFITS • Automated Cell Dropping • Automated Probe/DAPI Dispensing • Automated Coverslipping • Improve Metaphase Spread Quality • Perform Up To 8 Assays On One Slide • Reduce Probe/Assay Cost • Remove The Need For Rubber Cement • 24 Slide Processing Capability • Real-Time Probe Inventory Management RESULTS The dropping process has remained a highly manual technique for years, leaving an automation void between harvesters and microscopes. CellWriter now completes the continuum, by automating the dropping process to deliver quality spread interphase and metaphase nuclei for analysis. The CellWriter S is a robotic workstation that produces slides for both Karyotyping and FISH. By integrating BioDot’s nanoliter dispenser (BioJetTM) with exquisite temperature and humidity control, we have developed a highly efficient system that Image 1: Metaphase cell labeled with X Centromere (green) and Y Centromere (red) probes. Cells couterstained with DAPI plus Vectashield. Image taken with the Zeiss Axio Imager. M1 using the 100x Oil objective. produces quality slides. BioDot further simplifies the workflow by introducing a new, patented slide technology. FISHArray SlidesTM enable multiplexed FISH assays and eliminate the need for rubber cement when preparing for hybridization (a step that is both messy and time consuming). The CellWriter S processes 24 slides per batch. Image 2 & 3 : Male metaphase and interphase cells labeled with X Centromere (green) and Y Centromere (red) probes. Cells couterstained with DAPI plus Vectashield. Image taken with the Zeiss Axio Imager. M1 using t

SPECIFICATIONS Dispense Volume Dynamic Range • 100nl to 10ul Dispense Volume Precision • ± 5% Humidity Control • Ambient to 70% RH ± 5% Slide Temperature • 4°C to 65°C +/- 1°C Fume Filtering • Specialty-blended Filter Media [i.e. Acid Gas, Mercury, Aldehyde, Ammonia] Dimensions (L x W x H) • 98cm x 56cm x 87cm (39in x 22in x 34in) w/ Normalization Option • 155cm x 56cm x 87cm (61in x 22in x 34in) • LIMS Integration • FISHArray Slides • Integrated Normalization CONFIGURATION Dispense Channels per System (Sample/Probe) • 1 Slides per Batch • Up to 24 Samples per Batch • Up to 12 Probes per Batch •...