AEROGEN PRODUCT GUIDE High performance aerosol drug delivery • Delivers significantly more medication in half the time 1 At the heart of every Aerogen device is our unique palladium vibrating mesh technology. • Improves patient response to treatment 2 • Works with and without O2 3 • Can be used with either a mask or mouthpiece 3 Aerogen vibrating mesh technology comprises a unique dome-shaped aperture plate perforated with over 1,000 precision formed tapered holes. Aerogen Ultra delivers 6X greater lung dose* Aerogen Ultra When energy is applied, the aperture plate vibrates at 128,000 times a second producing a low-velocity, fine particle, nebulised mist of consistently sized droplets (1-5μm)1 to achieve superior lung deposition of medication.2, 3 Lung dose delivered: Ultra (34.1%), jet neb (5.2%) (p<0.001) Residual dose volume: Ultra (2.4%), jet neb (62.8%) (p=0.008) Nebulisers were filled with diethylenetriaminepentaacetic acid labelled with technetium-99 m (99mTc-DTPA, 2 mCi/4 mL) Dugernier J. et al 2017 4 *Aerogen Ultra compared to a standard jet nebuliser. SUPERIOR PATIENT CARE WITH AEROGEN ULTRA In a comparison study with a jet nebuliser, Aerogen Ultra resulted in a: reduction in ED admission rates 5 reduction in ED median length of stay 5 1. Hickin S. et al. Poster at the College of Emergency Medicine Clinical Excellence Conference 2014 2. Cushen B, et al. BTS poster presentation. 2016 3. Aerogen Solo Instruction Manual 4. Dugernier J. et al Pharmaceutical research. 2017;34:290-300. 5. Dunne R et al. Poster at the American Association for Respiratory Care. 2016. 1. Aerogen Solo Instruction Manual. 2. Dugernier J. et al Pharmaceutical research. 2017;34:290-300. 3. Galindo-Filho VC et al. Respir Care 2015;60(9):1238–1246 Discover Better Discover Better

AEROGEN CONTINUOUS NEBULISATION TUBE SET Aerogen can be used across all modalities for ventilated and non-ventilated patients • Quick and easy to set up 1 • Virtually silent 2 • Single patient use 1 Works with standard syringe pumps1 Aerogen Solo achieves superior drug delivery* Mechanical Ventilation Non-standard luer connectors eliminate the risk of misconnection Precise volumetric dosing for reliable, controlled aerosol delivery1 Aerogen Solo Aerogen Solo Nominal Dose % Aerogen patient side of leak expiration port compared to other groups AEROGEN POWER SOURCES Patient side of leak expiration...