Clearing Melasma with NeoSkin byAerolase® Facts, Figures and Mechanism of Action Pathogenesis of Melasma12 1. Factors include genetic predisposition, UV radiation exposure, sex hormones, and inflammatory processes 2. Multiple pathways become signaled Common Current Treatment Options7 8-9'10 Prevention: sun-protective measures including sunscreen and melanogenesis suppressors Epidermal: requires combination such as chemical peels to remove excess pigment and hydroquinone to suppress melanogenesis Dermal: no common or first-line therapy. Traditional light-based therapies cause high incidence of rebound melasma, hypo-, or hyperpigmentation • Most often affects women with skin types III - V • 40% of Southeast Asian women • 50-80% Latin women • 50-70% of pregnant women in the USA • Patients with even mild melasma report negative effects on emotional, social, and psychological well being // Management of melasma can be challenging and requires long-term treatment with topical agents. The results are often unsatisfactory and topical agents may sometimes cause significant adverse reactions11. 650-microsecond device comprehensively addresses melasma: Clears epidermal pigment, clears dermal pigment, and suppresses vasculature supporting melanogenesis. Mechanism of Action: Deep-penetrating energy breaks up epidermal and dermal melanin while suppressing vascular component Better Patient Experience and Outcomes: • Safe, effective, and tolerable for patients of all ages and skin types without side-effects • Comprehensively addresses dermal melasma, epidermal melasma, and the vascular components of melasma • May be used as foundation therapy before authorizing the use of topical therapies that may have side effects • Can be combined with peels or other topicals for comprehensive, quicker clearance aerolase www.aerolase.com (877) 379-2435 [email protected] ©2018 Aerolase Corporation. Ail rights reserved. RevOI .032818 NeoSkin”Contact Aerolase to get Started with Comprehensive Melasma Clearance.

Clearing Melasma with NeoSkin byAerolase® Clinical Photos After 2 Tx NeoSkin Treament Only Photos Courtesy of Wendy Roberts, MD After 3 Tx Combined with Isomer Peel Photos Courtesy of Yael Halaas, MD, FACS After 1 Tx Combined with Hydroquinone 6% Photos Courtesy of Cheryl Burgess, MD After 1 Tx Combined with TCA 6% Peel (PCA® Sensi Peel®) Photos Courtesy of Suneel Chilukuri, MD After 1 Tx Combined with TCA Peel Photos Courtesy of Yelena Kipervas, DO 1. Grimes PE: Melasma: Etiologic and therapeutic considerations. Arch Dermatol 131:1453-1457,1995 2. Kim EH, KimYC, Lee ES,etal: The vascular characteristics...