AGILENT SOLUTIONS FOR METABOLOMICS - 12 Pages

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AGILENT SOLUTIONS FOR METABOLOMICS

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YOUR Path To Success AGILENT SOLUTIONS FOR METABOLOMICS

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Understanding METABOLOMICS Agilent is the leading global solution vendor for measuring metabolism, offering researchers a broad array of cutting-edge instrumentation and innovative informatics solutions. What is Metabolomics? Metabolomics is the study of endogenous metabolites, called the metabolome, which is a collection of low molecular weight (50-1,500 Da) compounds with a wide range of physiochemical properties. Measuring the metabolome provides important information about the functional status of a biological system. Its close proximity to the phenotype of an organism provides...

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METABOLOMICS TOOLS FOR A VARIETY OF RESEARCH APPLICATION 4    -A* Basic and clinical Research Identify and verify metabolite biomarkers that correlate with disease states as well as provide fundamental insights into biology Agriculture Identify and understand metabolic pathways to optimize crop development, yield improvement, and pesticide/ herbicide resistance Food and Nutrition Identify the presence or absence of metabolites that correlate with major traits such as food quality, authenticity, taste, and nutritional value, and aid in the development of nutraceuticals Pharmaceutical...

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Discovery METABOLOMICS Discovery metabolomics typically involves global profiling of metabolites by hyphenated MS techniques. Following separation and detection of compounds, features are found across all data files. The results are statistically analyzed and differential features are identified. The identified metabolites are visualized on biological pathways to aid interpretation. Data Acquisition Feature Finding · GC/MS · CE/MS · LC/MS · SFC/MS · Mass Hunter Profinder · Mass Hunter Qual Pathway Analysis · Mass Profiler Professional · Agilent Fiehn Library · Agilent METLIN PCDL · Pathway...

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Targeted Metabolomics Targeted metabolomics experiments focus on measuring specific metabolites. Triple quadrupole mass spectrometers are best suited for this task because of their broad dynamic range, highest sensitivity, and selectivity for compound confirmation. Data Acquisition · GC/MS · CE/MS · LC/MS · SFC/MS Targeted Metabolite Extraction Statistical Analysis Pathway Analysis · Mass Profiler Professional · Pathway Architect · Mass Hunter Quant Agilent workflow for targeted metabolomics research Agilent’s triple quadrupole LC/MS and GC/MS systems provide sensitive detection over a large...

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Software Tailored to Your Metabolomics Research Needs Metabolomics researchers face a serious challenge analyzing sets of data that are becoming increasingly large and more complex. Multivariate statistics are commonly used to find differences between sample groups. However, it’s not enough to know what metabolites are differential; understanding the biological context is critical. Projecting and visualizing processed data sets onto metabolic pathways utilizes existing knowledge and facilitates biological understanding. Agilent offers advanced analysis software for processing and...

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"Compound identification is a major bottleneck in metabolomics. To address this challenge, I am pleased to collaborate with Agilent Technologies to help them develop the METLIN Personal compound database with MS/MS spectral library, and I look forward to our continued efforts with Agilent to develop new tools that benefit the metabolomics community.“ Gary Siuzdak, Ph.D., Senior Director, Scripps Center for Mass Spectrometry Pathway Analysis By incorporating a pathway-centric workflow into omics experiments, scientists can concurrently focus on the analysis, and potentially accelerate the...

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Software Tailored to Your Metabolomics Research Needs Qualitative flux analysis allows researchers to quickly obtain information about selected pathways and fluxes using stable isotope label tracing with mass spectrometric analysis. Qualitative flux analysis presents multiple analytical challenges such as mining the target metabolites, accounting for isotopologues, correcting for naturally occurring isotopes, and visualizing the results in a biological context. MassHunter VistaFlux is software designed to meet these challenges and is designed as a qualitative flux analysis solution for...

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A Powerful Way to Investigate Biology An Innovative Approach to Metabolism Metabolic Rates in Minutes Measuring functional metabolism in live cells and determining the metabolic phenotype provides a powerful guide for metabolomics experimental design. Seahorse XF Analyzers measure the activity of the two major energy-producing pathways of the cell – mitochondrial respiration and glycolysis – in live cells, in real time. Agilent Seahorse XF Analyzers provide a downstream approach to measuring cellular bioenergetics, enabling rapid assessment of metabolic function in live cells under multiple...

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AGILENT’S METABOLOMICS SOLUTIONS GC/MS Instruments and Databases The Agilent 5977B High Efficiency Source GC/MSD system incorporates an ultraefficient electron ionization source to maximize the number of ions created and transferred into the analyzer, revolutionizing single quadrupole performance. The Agilent 7000 and 7010 Series Triple Quadrupole GC/MS systems provide low detection limits, robust performance, and software tools that make it easy to optimize your methods. The Agilent 7200B GC/Q-TOF system delivers high sensitivity and selectivity with the added value of accurate mass and...

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LC/MS Instruments and Databases The Agilent 6200 Series Accurate-Mass TOF LC/MS systems provides the ability to identify both small molecules and large biologic compounds with high resolution, accurate mass analyses data for maximum value in qualitative assays. The Agilent 6500 Series Accurate-Mass Q-TOF LC/MS brings the power of accurate mass MS/MS to provide strong confidence in identifying, screening, profiling, or quantitation in complex samples. The Agilent 6400 Series Triple Quadrupole LC/MS systems provides triple quadrupole performance that gives you superior sensitivity, renowned...

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