Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond
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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 1

Agilent Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond Open Access LC and LC/MS using Agilent MassHunter WalkUp software

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 2

Enable Robust Open Access LC or LC/MS Analysis with a Single User Interface Announcing the latest evolution of Open Access software for LC and LC/MS users, based on years of feedback from Agilent customers. These capabilities open new doors for applications such as: Agilent MassHunter WalkUp software lets your lab access and administer Agilent OpenLab CDS ChemStation Edition, OpenLab CDS 2.X, and MassHunter-controlled LC and LC/MS (LC/MSD, TOF, and Q-TOF) instruments. – Characterizing peptides and large molecule therapeutics. That includes analyzing intact proteins, peptides, and antibody...

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 3

Simple, Convenient Sample Submission With MassHunter WalkUp software, chemists and biologists can submit their samples in four easy steps: 1. Log in Enter username, password (optional), workflow, and number of samples. 2. Select method Enter sample details and choose from a list of methods. 3. Load sample Place the sample in the location indicated. Classic Open Access screens are still available, and can be configured on a system-bysystem basis. 4. Receive report Choose from formats such as PDF, ASR, and Excel.

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 4

See More Compounds in Your Sample Our LC/MS portfolio gives you unprecedented flexibility for analyte-agnostic workflows - Choice of ionization sources: ESI, APCI, APPI, or Multimode (APCI+ESI) - Fast positive/negative switching for narrow UHPLC peaks - Sensitive detection for low-level components - Divert valve for reduced contamination - External tray for sample submission and automatic discard of used vials - Mass-based fraction collection - Localized sample submission screens in Chinese and Japanese Molecular weight Very polar Select from multiple ionization techniques for all analyte...

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 5

How Does MassHunter WalkUp Benefit Analysts? The MassHunter WalkUp environment simplifies sample submission and gives every analyst—regardless of experience—hands-on access to LC/MS capabilities Overcome Open Access LC/MS implementation challenges for biomolecules Take full advantage of high-resolution TOF and Q-TOF measurements by integrating MassHunter WalkUp and MassHunter BioConfirm. This combination gives biologists an Open Access environment previously available only for small molecule analysis, which eliminates risk, increases efficiency, and automates the interpretation of results....

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 6

Many Applications, One Centralized Solution Using MassHunter WalkUp to manage your LC and LC/MS applications increases efficiency, consistency, and throughput with fully automated solutions. You’ll also minimize errors associated with maintaining diverse workflows. Compound verification and purity assessment CH3O 609.2771 +ESI Scan (rt: 1.562-1.651 min) Frag=400V Reserpine_ QTOF_1pgms3.d 610.2803 Upload expected formula or molecular weight Chromatographic separation Peak detection Assess peak MS spectra Mass-based fraction collection CH3O Sample submission Upload expected formula or...

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 7

Compare expected monoisotopic mass to observed m/z considering adducts High throughput compound purity assessment with Analytical Studio Reviewer software IT Fraction purity Fraction pooling Determine post- Sequence coverage translational modifications

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 8

Simplified LC/MS for Everyone Optional BioConfirm and ADC DAR Calculator Make LC/MS accessible to all biologists and chemists. MassHunter WalkUp works seamlessly with BioConfirm and ADC DAR Calculator to enable protein confirmation, ADC DAR calculation, and peptide mapping with PTM identification. MassHunter BioConfirm streamlines data processing for therapeutic proteins.

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 9

Analytical Studio Reviewer Enable quick visualization of results and selective data review—especially for larger sample sets, like whole plates. With Analytical Studio Reviewer, results files can be emailed to users. These files open into a viewer, allowing users to browse the results and navigate to problem samples quickly. By eliminating the need for chemists to have data analysis software at their desks, Analytical Studio Reviewer can significantly reduce costs for large installations. Quickly picture and review data using Analytical Studio Reviewer.

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 10

How Does MassHunter WalkUp Benefit Administrators? MassHunter WalkUp provides powerful-yet-straightforward system administration to meet the needs of a diverse user base. So your lab can maximize uptime and minimize training costs. With MassHunter WalkUp, a single administrator can: – Easily manage many systems and workflows. – Customize sample submission screens on a system-by-system basis. – iew instrument status remotely. V – dd, modify, or delete user profiles and methods. A – eceive system error notifications by text message or email. R And when it’s time for maintenance, you can take...

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 11

Manage MassHunter and OpenLab Controlled Instruments With OpenLab Shared Services, MassHunter WalkUp can manage your lab from anywhere on the network. Because the settings are hosted on a central server, you can immediately implement the data system (OpenLab CDS ChemStation Edition or MassHunter) and any updates. So there’s no need to attach an instrument. Agilent 1290 Infinity II Autoscale Prep LC/MSD OpenLab Shared Services

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Reliable LC/MS for Medicinal Chemists, Peptide/Protein Chemists, Biologists, and Beyond - 12

Agilent CrossLab services CrossLab is an Agilent capability that integrates services and consumables to support workflow success and important outcomes like improved productivity and operational efficiency. Through CrossLab, Agilent strives to provide insight in every interaction to help you achieve your goals. CrossLab services include method optimization, flexible service plans, and training for all skill levels. We have many other products and services to help you manage your instruments and your lab for best performance. Learn more about Agilent CrossLab, and see examples of insight...

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