pNeuton Pneumatic Transport Ventilation Performance of pNeuton using Respiratory Care 2007 Test Protocol Performance Comparison of 15 Transport Ventilators published in June 2007 issue of Respiratory Care*. The original study did not include the pNeuton Ventilator as animal studies were already underway when Airon approached the authors. Subsequently, Massachusetts General has tested the pNeuton ventilator and found it to meet the targets set in the study protocol. To allow comparison of pNeuton with the ventilators in the study, we have repeated the exact procedure the authors used for the laboratory bench tests. pNeuton results are as follows: 500 ml Tidal Volume Rate High Resistance Normal Compliance Normal Resistance Normal Compliance Normal Resistance Low Compliance 1000 ml Tidal Volume Rate High Resistance Normal Compliance Normal Resistance Normal Compliance Normal Resistance Low Compliance The pNeuton ventilator performs as specified under the conditions of the test protocol. All values are better than the 10% accuracy required. pNeuton was able to ventilate under normal lung and injured lung conditions. Even in the worst case conditions where the peak pressure was 50 cm H2O. All tests were performed with the ventilator set for 65% oxygen. Comparison with other ventilators in the study 1. 2. 3. 4. “Sophisticated” ventilators – pNeuton performs as good as or better Pneupac ventilators – their delivered tidal volumes were inaccurate in 50% of tests Oceanic (Maxtec) ventilators - their delivered tidal volumes were inaccurate in 90% of tests Carevent ventilators - their delivered tidal volumes were inaccurate in 80% of tests Conclusion The pNeuton ventilator met all trial targets using the bench test criteria. We did not perform the animal tests but are confident the ventilator would meet those trial targets as well. The article did not examine spontaneous breathing performance. This functionality is extremely important, as pointed out by the authors. The pNeuton ventilator’s demand valve response time and internal PEEP / CPAP supports both noninvasive and invasive spontaneous breathing. * Chipman DW, et al. Performance Comparison of 15 Transport Ventilators. Respir Care 2007;52(6):740-751 Airon Corporation 751 North Drive, Unit 6, Melbourne, FL 32934 USA tel 888-448-1238 (USA toll free) 321-821-9433 fax 321-821-9443 CD-A-037 Rev A

Performance Comparison of 15 Transport Ventilators Daniel W Chipman RRT, Maria P Caramez MD, Eriko Miyoshi MD, Joseph P Kratohvil RRT, and Robert M Kacmarek PhD RRT FAARC BACKGROUND: Numerous mechanical ventilators are designed and marketed for use in patient transport. The complexity of these ventilators differs considerably, but very few data exist to compare their operational capabilities. METHODS: Using bench and animal models, we studied 15 currently available transport ventilators with regard to their physical characteristics, gas consumption (duration of an E-size oxygen cylinder), battery...

PERFORMANCE COMPARISON Table 1. Comparison of Evaluated Ventilators by Power Source, Physical Dimensions, Modes, FIO2, and PEEP Approved as Transport Ventilator Size Power Requirement Weight Height Width Depth (kg) (cm) (cm) (cm) Available Modes FIO2 (range or available values) PEEP Available? (range cm H2O) Sophisticated Univent Eagle 754 VersaMed iVent Electricity Electricity A/C, SIMV CMV, SIMV CMV, SIMV CMV, IMV CMV, IMV CMV, IMV A/C (VP), SIMV (VP), PSV, CPAP A/C, SIMV CMV, IMV Simple Oceanic Medical Products Magellan Bio-Med Devices IC2A Pneupac Parapac Medic Pneupac Parapac Transport 200D...

PERFORMANCE COMPARISON as the amount of time the ventilator could function on a fully charged battery with the ventilator set to deliver a VT of 1,000 mL at an RR of 10 breaths/min and an FIO2 of 0.21. A ventilator was considered easy to use if all the parameters were clearly labeled and easily set to deliver a precise variable (eg, VT or RR). We assumed the manufacturer’s published weight and dimensions to be accurate. Ability to ventilate without compressed gas was met if the ˙ ventilator could deliver the set minute volume (VE) under each of the test conditions without a compressed gas source...

PERFORMANCE COMPARISON gases and hemodynamics were evaluated to determine if the target blood gas values (PaO2 60 –100 mm Hg, PaCO2 30 –50 mm Hg, pH 7.30 –7.50) had been met, then the ventilator was adjusted as necessary to attempt to meet the targets. Once we determined whether the targets could be met, the next ventilator was attached to the animal’s airway for evaluation. Instrumentation We used 12 female Dorset sheep (21–31 kg), each fasted for 24 hours. Orotracheal intubation, with an 8-mm innerdiameter ETT, was performed during deep halothane anesthesia via mask. The external jugular vein...

PERFORMANCE COMPARISON Table 2. Operational Features of Evaluated Ventilators: Battery, Gas Consumption, Alarms, and Ease of Use Sophisticated Univent Eagle 754 VersaMed iVent Newport HT50 Pulmonetic Systems LTV 1000 Simple Oceanic Medical Products Magellan Bio-Med Devices IC2A Pneupac Parapac Medic Pneupac Parapac Transport 200D Life Support Products AutoVent 2000 Carevent ATVϩ Vortran RespirTech Pro࿣ Percussionaire TXP࿣ Bio-Med Devices Crossvent 3** Bird Avian** Pneupac Compac 200 Battery Powered Battery Life* Oxygen Cylinder Duration (min)† Disconnect Alarm HighPressure Alarm Able to Ventilate...

Normal Resistance and Normal Compliance Normal Resistance and Low Compliance High Resistance and Normal Compliance Bench Performance at a Tidal Volume of 500 mL Sophisticated Transport Ventilators Univent Eagle 754* Univent Eagle 754‡ VersaMed iVent* VersaMed iVent‡ Newport HT50* Newport HT50‡ Pulmonetic Systems LTV 1000* Pulmonetic Systems LTV 1000‡ Simple Transport Ventilators Oceanic Medical Products Magellan* Oceanic Medical Products Magellan‡ Bio-Med Devices IC2A* Bio-Med Devices IC2A‡ Pneupac Parapac Medic* Pneupac Parapac Medic‡ Pneupac Parapac Transport 200D* Pneupac Parapac Transport...