Introducing PhenoCode Signature Panels

Product catalog summary

Introduction to PhenoCode Signature Panels
PhenoCode Signature Panels are designed to enhance the predictive accuracy of combination therapies by utilizing spatial phenotyping. This approach is particularly effective in predicting patient responses to anti-PD-1/PD-L1 therapies, surpassing traditional biomarker modalities.

Key Features

Specificity and Sensitivity: Spatial phenotyping offers higher predictive accuracy compared to NGS, RNA expression, and standard PD-L1 IHC tests.
Flexibility: The panels allow for the integration of additional markers, enabling researchers to address specific questions related to the tumor microenvironment (TME).
Speed: Development of spatial signatures is accelerated by three times, facilitating rapid biomarker discovery.
Scalability: Discoveries can be seamlessly translated into predictive biomarkers using the PhenoImager® solution.

Case Study: AstroPath Signature
Researchers at Johns Hopkins University developed spatial signatures using sky mapping algorithms and the PhenoImager platform, achieving high accuracy in predicting immunotherapy responses (AUC >0.80).

Panel Composition

5-Plex Base Panels: These include markers such as CD8, CD68, PD-L1, FoxP3, and PanCK, among others, allowing for comprehensive analysis of immune cell status and tumor characteristics.
Customizable Options: Researchers can add specific markers to address unique research questions.

End-to-End Solution
The PhenoCode Signature panels provide a complete solution for spatial signature development, integrating staining, imaging, and analysis. This system is optimized for accuracy and reproducibility, significantly reducing assay development time.

Conclusion
PhenoCode Signature Panels represent a significant advancement in the development of predictive biomarkers for combination therapies, offering flexibility, speed, and scalability to researchers in the field.

Catalog excerpts

Introducing PhenoCode Signature Panels-1

DESIGNED FOR THE EVER-CHANGING COMBINATION THERAPY LANDSCAPE

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Introducing PhenoCode Signature Panels-2

PREDICTIVE SPATIAL SIGNATURES FOR THE NEXT GENERATION OF COMBINATION THERAPIES Get Higher Predictive Accuracy INTRODUCING PHENOCODE SIGNATURE Designed for the ever-changing combination therapy landscape The development of clinically useful biomarkers to select responders for combination therapies will be critical for the advancement of such treatments. A recent meta-analysis1 has shown that spatial phenotyping, enabled by multiplexed imaging, more accurately predicts patient response to antiPD-1/PD-L1 therapy than other biomarker modalities. Spatial signatures are a novel biomarker class developed...

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IMMUNO-CONTEXTURE PANEL FLEXIBILITY TO ANSWER MORE QUESTIONS QUICKLY Decode the science of response to combination therapy PhenoCode Signature panels are designed to provide flexibility, allowing for the easy integration of one additional marker to a 5-plex panel. Analyze additional cell phenotypes or address your specific research question with your own marker of choice. IMMUNE PROFILE PANEL Where are the immune cells in the TME? ACTIVATED TIL STATUS PANEL Are the tumor cells proliferating or lymphocytes activated? PhenoCode™ Signature PhenoCode Signature 5-Plex Base Panels Where are the TAMs...

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SPEED UP SPATIAL SIGNATURE DEVELOPMENT BY 3X THE PERFECT END-TO-END SOLUTION FOR SPATIAL SIGNATURE DEVELOPMENT PhenoCode Signature panels are optimized and validated to enable the rapid development of spatial signatures by shortening the assay development time by 3X. The development of spatial signatures requires a solution that easily integrates staining, imaging, and analysis using existing workflows while providing accuracy and reproducibility. ASSAY DEVELOPMENT AND OPTIMIZATION Custom-built 6-plex panel PhenoCode Signature 6-plex panel 3X REDUCTION CASE STUDY Spatial Signature Spotlight The...

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Introducing PhenoCode Signature Panels-5

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