ALBA_Hyperthermia_4D
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DEEP HYPERTHERMIA SYSTEM - Multichannel phased array system for deep hyperthermia

AlbA^D _ DEEP HYPERTHERMIA SYSTEM _ ALBA 4D is a phase control, loco-regional deep hyperthermia system conceived and designed in full compliance with the Q.A. GUIDELINES of the ESHO - European Society for Oncological Hyperthermia and the latest radiotherapy standards. The ALBA 4D project is inspired by the AMC 4/8 systems developed by the hyperthermia team of the Academic Medical Center of Amsterdam. Since the early 80’s the AMC Cancer Research Center has been one of the most active institutes in the use of hyperthermia with more than 2,400 patients successfully treated. Numerous scientific...

HYPERTHERMIA AND RADIOTHERAPY In HT electromagnetic energy is used to increase the temperature of a target in the range of 41 °- 43°C in order to enhance the effect of radiotherapy and chemotherapy, without damaging normal tissue. Many studies have shown that HT, in combination with RT, moves the tumor control towards a lower radiation dose thus allowing for higher tumor control with unchanged radiation dose and unchanged tumor control at lower radiation dose. HYPERTHERMIA AND CHEMOTHERAPY The cytotoxicity of many chemotherapeutic drugs is modified by heat, converting sublethal DNA damage...

DOSIMETRY ALBA 4D is equipped with a real-time dosimetry system, which is positioned in the natural cavities of the pelvic region: - Multi-point temperature probes - Miniature optical E-field sensor for an in-vivo optimization of the treatment setting. SENSORS SUPPORT DEVICES In order to guarantee the reproducibility of their position and good tissue contact of the thermometric and E-field sensors, ALBA 4D is equipped with specific support devices approved by the ESHO guidelines. HTPS ALBA 4D is provided with treatment planning software developed by AMC for treatment simulation. The aim is...

ALBA4D The ALBA 4D is composed of a phased array of four antennas and a mechanically removable bed for patient positioning during treatment. One of the four antennas of the array is embedded directly into the table and is fixed. The other three antennas are positioned on the arched gantry around the bed and can move toward the patient. The arch as a whole can move vertically. BED MOVEMENT Manual positioning of the bed allows for an easy and comfortable patient preparation and fast emergency patient removal. VENTILATION The ventilation system is composed of 4 fans which can be regulated for...

POWER DELIVERY AND CONTROL SYSTEM The 4 radiofrequency signals are generated through a synchronized multichannel digital generator unit (DDS) and amplified to 500W/channel. An embedded and robust feedback system for phase /amplitude control allows for focus stability in the ROI. THERMOMETRIC SYSTEM The 64 channel thermometric system consists in multi-point probes containing 0.5/1 cm spaced thermocouples. The signals generated by the thermocouples are acquired and pre-conditioned by the electronics contained within the thermometric box, integrated within the structure of the bed. QUICK...

PATIENT POSITIONING ALBA 4D is equipped with a laser pointing system for optimal patient positioning during treatment. The system records the position of the antennas and the patient during each treatment. This allows for both the reproducibility of the antennas/patient positioning throughout all the treatments, as well as the collimation of the antennas/patient block with the ALBA HTPS simulation software. INTEGRATION WITH RADIOTHERAPY PACS SYSTEM The ALBA 4D software is designed to be fully integrated with the radiotherapy PACS systems in order to more easily introduce hyperthermia into...

performance over time. QUALITY ASSURANCE The ALBA 4D system is equipped with an AMC ESHO-approved quality assurance kit consisting in a tissue equivalent phantom and a LED matrix to control the deposition of the system’s electromagnetic power and the focus steering capability. These will ultimately guarantee an optimal system SITE PLANNING A RF shielded room is required for ALBA 4D installation. A standard ALBA 4D treatment area consists in a treatment room which may include an operator console, a technical room and a changing room. Our designers provide also guidelines for the layout of...

4-CHANNELS DIRECT DIGITAL SYNTHESIS GENERATOR AT 70 MHz Dynamic phase control: 0°^360° Phase resolution: 0.04° Phase accuracy: ±0.2° Amplitude and phase control loop Maximum power level: +20dBm 4 RF POWER AMPLIFIERS RF 4-channel Amplifier70 MHz Output Power Range: 0.5 W -500 W Total power: 2000 W Output Power Resolution: 0.01dB Output Power Accuracy: +/-0.1 dB Computerized thermoregulation system of distilled water Range: 15°C^40°C Accuracy: ±0,3°C Flow Rate: 25 lts./min Reserve tank capacity: approx. 80 lts. 4 APPLICATORS AND WATER BOLUS GANTRY/PATIENT’S BED 4 waveguide applicators...

HEADQUARTERS Medlogix is based in Rome’s Tiburtino Technology Park, known worldwide for companies partnering in precision engineering and electronics, radar technology, and space telecommunications. The area is home to more than 80 high-tech business ventures run by enthusiastic young engineers and researchers. TEAM The ALBA team is composed of physicists and RF electrical and medical engineers dedicated exclusively to the development of innovative technology for hyperthermia in oncology, many with expertise in radar technology. The team works closely on innovative projects with leaders in...

PROJECT LEADER & PRODUCER MAIN PARTNERS Medlogix holds exclusive rights over the material contained in this brochure. The reproduction and diffusion of all parts of the same is strictly forbidden without a prior and specific authorization by Medlogix. In case of misuse Medlogix reserves legal action to protect its rights. Medlogix Sri Via Andriano Olivetti, 24 - 00131 Roma Tel: +39 06 40043808 Fax: +39 06 40043809 www.albahypertermia.com info@medlogix.eu