Alere Pima CD4 Analyser
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actual size Alere Pima™ CD4 Reaching Further

Innovative: It is the first point-of-care, portable CD4 test ideal for both decentralized and centralized settings Accurate The Alere Pima™ CD4 Test generates absolute CD4 + count, equivalent precision and accuracy as compared to the lab tests1,2 Convenient Compact and portable, the Alere Pima™ CD4 Test provides results anytime, anywhere. Flexible Requires only a small amount of blood allowing for fingerstick or venous whole blood samples. Efficient It offers a one stop, same-day-result for absolute CD4 count in less than 20 minutes.

Extending the reach ofof HIV care Extending the reach HIV care Since its identification in 1981, HIV has become a global pandemic. With over thirty three million cases worldwide and over 2.5 million new cases each year, this disease has become a global burden over the past thirty years. But, there is hope. Thanks to new technology and scientific breakthrough, HIV has become more manageable. Alere is at the forefront of these advancements, working to provide tools to help monitor those with HIV and provide results that put them on the path to better health. The Alere Pima™ CD4 Test is a...

Lab quality CD4reach of  n your hands Extending the results i HIV care Lab Accurate CD4 Count – anytime, anywhere The Alere Pima™ Analyser employs the same static image analysis and counting principles as existing CD4 enumeration technology, in a compact, portable and robust package at the point-of-care. Thoroughly validated in numerous independent studies the Alere Pima™ CD4 Test, consistently delivers results comparable to those obtained using conventional lab based flow cytometry methods. Results show that when comparing the Alere Pima™ CD4 Test to a gold standard laboratory CD4 Test,...

Conventional CD4 vs Alere Pima™ CD4 3 r = 0.952 p = 0.000 Difference (Pima™ CD4 – Conventional CD4) Both charts adapted from: Baker, C.K. 2011

Results at your fingertipsHIV care Extending the reach of The Alere Pima™ CD4 Cartridge is a breakthrough technology enabling the use of whole-blood fingerstick or venous EDTA whole blood samples to identify T-helper cells and establish an absolute CD4 count. Insertion of the Alere Pima™ CD4 Cartridge into the Alere Pima™ Analyser automatically starts the testing process providing you with a direct CD4 measurement in less than 20 minutes. 25 μL of venous or fingerstick whole blood Uses lab or point-of-care samples No manual sample handling or processing No sample transfers, no time spent...

Control window sample volume Detection channel

Reduce the the reach complexity Extending workflow of HIV care of your CD4 testing 1. Collect Sample • Check sample volume • Remove sample collector and cap cartridge 2. Run Test • Insert capped Alere Pima™ CD4 Cartridge in the Alere Pima™ CD4 Analyser • Result in less than 20 minutes 3. Read Result Screens • iew and read absolute V CD4 results

The simplicity of the Alere Pima™ workflow reduces the complexity of delivering your CD4 result to the patient. Once a patient sample is loaded and sealed within the Alere Pima™ CD4 cartridge the operator simply needs to insert the cartridge in the Analyser, enter an Operator ID then a Sample ID and in less than 20 minutes your result is delivered. CD4 Testing: The Alere Pima™ Way Patient visits the local clinic or the health care worker may travel to the patient Patient and test are at the same place at the same time Waiting time to result just 20 minutes The patient ob­ tains CD4 result...

The sciencethe reach of HIV care Extending behind accurate absolute CD4 count results The dried reagent sealed within the Alere Pima™ CD4 test cartridge contains CD3 and CD4 detection markers. Once the sample is loaded onto the cartridge, the reagents are dissolved into the blood sample. At this time the sample interacts with CD3 and CD4 specific monoclonal antibodies each labelled with a different fluorescent dye. The stained sample is then spread along the detection channel to await image capture. T-helper cells are automatically detected by determining where fluorescent signals from both...

Red (PECy5) Green (PE) CD3 CD4 antibody antibody Cell labeled with Green Dye Cell with two antibodies co-localized Unrecog­ nized cell Cell labeled with Red Dye

Whether testing reach of HIV care Extending the in remote settings in Africa or at a clinic in London, … Decentralized Testing Routinely, healthcare providers in remote settings wishing to test HIV positive patients’ absolute CD4 count are faced with the challenge of not only transporting a patient sample to test sites, but also providing the results back to the patient. Consequently, many patients are lost to follow up.4 The portable analyser provides you with accurate, dependable CD4 results in less than 20 minutes at the point-of-care, without the use of a lab-allowing you to make...

… the Alere Pima™ Test provides accurate results anywhere, anytime Centralized Testing Ensuring that you have a full picture of your HIV positive patients is important – to you and your patient. Unfortunately, costly and timely lab tests can make this difficult. The Alere Pima™ CD4 increases efficiencies and empowers healthcare providers with the tools at the point-of-care for better patient management by delivering results at point-of-care allowing you to make decisions faster. “ The point-of-care CD4 provides a result in 20 minutes, is highly correlated with the laboratory CD4 tests and...

Reducing complexity: of HIV care Extending the reach Putting Patients on the path to better health faster As the world’s first point-of-care CD4 test the Alere Pima™ CD4 Test opens the gateway to increased access to CD4 testing and improved patient outcomes. Increasingly studies are finding that pointof-care diagnostic solutions are empowering health professionals to positively impact the health of their patients. Health programmes such as those in rural Mozambique are already showing the benefits provided by the Alere Pima™ CD4 test observing installation of the Alere point-ofcare CD4...