POLYPURE® H High Flux Series POLYPURE® H–Allmed’s high flux dialyser, using our micro-undulated polysulfone membrane. Manufactured and developed by Allmed in our world class fibre production facility in northern Germany. POLYPURE® H is the ideal dialyser to perform Haemodiafiltration (HDF) or High Flux Dialysis (HFD) therapies, offering optimal clearances for middle molecules, but with the added benefit of albumin retention. Micro-undulated technology: highest efficacy Micro-undulation technology ensures the highest efficiency and clearances thanks to “bundles” and “dead-zones” prevention together with the optimally increased surface exchange of blood-membrane-dialysate. Optimal middle molecule removal and albumin retention: Safeguarding patient nutritional status 1.0 Our optimal membrane structure perfects the delicate balance between substantial middle molecule removal and loss of albumin. POLYPURE® H is characterised by excellent S & C for ß2 microglobulin (0.85) and for myoglobin (0.45), while albumin loss
is practically negligible (SC < 0.001). POLYPURE® H is the best choice for effective HDF or HFD treatments. Protection from endotoxins: reduced inflammation SIEVING COEFFICIENT POLYPURE® asymmetrical membrane with an optimised micro-undulated fibre structure and a 40μm thickness prevents endotoxin transfer thanks to its geometrical and adsorption capacity capability. Systemic inflammation is well recognised to be associated with an increased cardiovascular disease risk in patients with chronic renal disease. Exposure to endotoxins results in a release of a wide variety of pro-inflammatory cytokines, with subsequent chronic systemic inflammation and a broad range of negative cardiovascular effects. Chronic inflammation can also modify the process of erythropoiesis and probably induces resistance to erythropoietin. Allmed | POLYPURE® H High Flux Series | allmedgroup.com Adsorption into the wall Sieving/ size exclusion Safe dialysis Bacteria free apyrogenic 40 µm protective wall

Allmed | POLYPURE® H High Flux Series | allmedgroup.com Clearance in vitro (ml/min) QD = 500 ml/min
 QF = 0 ml/min
 T = 37oC Max TMP = 500mmHg Blood priming Volume (ml) Sieving coefficient • Performance data was measured in vitro according to standard ISO 8637 • UF measurement: using bovine/human blood (Hct 32%;protein 60g/l) • Typical values obtained with an individual batch of fibres, clinical use may illustrate a difference in results in relation to different Ultrafiltration/measuring techniques and possible variation between batches of fibres Membrane material Micro-undulated polysulfone...