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Overview: The ALPCO Product Catalog for 2013-2014 offers a comprehensive list of immunoassay-based products for research in areas such as allergy, bone metabolism, cardiovascular diseases, diabetes, endocrinology, gastroenterology, immunology, neurobiology, toxicology, and flow cytometry. ALPCO, established in 1991, has expanded its offerings to include HPLC, LC-MS/MS, purified antibodies, recombinant proteins, and flow cytometry reagents.

Company Background: Initially an importer and distributor of immunoassay products in North America, ALPCO partnered with Bühlmann Laboratories. Over two decades, it has grown to represent over 60 global partners and launched its own product line focused on diabetes and obesity research.

Product Highlights: The catalog features various ELISA kits for detecting antibodies related to infectious diseases and allergens. The exclusive FlowCAST® Basophil Activation Assays offer a reliable method for allergy determination using flow cytometry, reducing the risk of anaphylactic events.

Allergy Testing: Traditional allergy testing methods like skin and IgE tests can be inconclusive, necessitating provocation tests. FlowCAST® assays provide a safer alternative by measuring basophil activation markers CD63 and CD203c.

Key Products: The catalog lists numerous ELISA kits for various pathogens and allergens, detailing their catalog numbers, sensitivity, sample size, and incubation times. Notable products include assays for Adenovirus, Anti-Candida, Anti-Helicobacter Pylori, and West Nile Virus.

Technical Support: ALPCO offers a responsive technical support team and a resourceful website with FAQs, technical tips, and interactive tools. Customers can access product specifications, protocols, and order online.

Conclusion: ALPCO continues to expand its product offerings, focusing on innovative solutions like the STELLUX line of chemiluminescent detection systems, while maintaining its mission to deliver scientific solutions for life.

ELISA Kits: The document lists numerous ELISA kits for detecting antibodies against various pathogens such as Parvovirus B19, Respiratory Syncytial Virus, Syphilis, Tetanus Toxin, Toxoplasma Gondii, Ureaplasma Urealyticum, Varicella Zoster, Visceral Leishmaniasis, and West Nile Virus. Each entry includes the catalog number, sample size, sample type, and incubation time, with specific protocols for cut-off values.

Allergens: The document categorizes allergens into drugs, environmental/occupational, food, inhalants, insect venoms, recombinant allergens, and allergen mixes. Each category lists specific allergens with their catalog numbers, indicating their use for research and diagnostic purposes.

Bone Metabolism: The document discusses bone metabolism, highlighting the balance between bone growth and resorption. It mentions diseases related to bone metabolism such as osteoporosis, osteopetrosis, Paget’s Disease, rheumatoid arthritis, cancer & bone metastases, and chronic kidney disease. It also lists various ELISA kits for bone metabolism markers like Vitamin D, Anti-TNF α Inhibitors, Bone Sialoprotein, Calcitonin, Cathepsin K, CTGF, DKK-1, DPD, Fetuin-A, hCOMP, Hydroxy Pyridinium Crosslinks, and IL-6.

Sclerostin: Sclerostin is highlighted as a key protein in bone formation regulation, with elevated levels associated with several bone-related diseases and conditions. It is identified as a potential therapeutic target in bone and cancer research.

Regulatory Information: The document notes that products are for research use only unless otherwise specified, with some being FDA registered for in vitro diagnostic use and Health Canada licensed.

Endocrinology Assays: The document provides specifications for different types of assays, such as ELISA, RIA, and HPLC, focusing on hormones, proteins, and other biomarkers relevant to endocrinology and gastroenterology.

Gastroenterology Insights: Calprotectin levels in feces are a reliable indicator of inflammation, useful for differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). Elevated fecal calprotectin levels correlate with histologic inflammation and can guide decisions on further diagnostic procedures like colonoscopy.

Regulatory Notes: Many products are for research use only, with some registered for in vitro diagnostic use by the FDA and licensed by Health Canada.

Diagnostic Markers for Rheumatoid Arthritis: The document references studies on the use of citrullinated peptides and proteins for diagnosing rheumatoid arthritis, highlighting the sensitivity and specificity of various immunoenzymatic methods.

Product Specifications: A comprehensive list of ELISA kits is provided, detailing their catalog numbers, detection ranges, sensitivity levels, required sample sizes, types, and incubation periods. These kits are used for detecting various proteins and antibodies in different sample types such as serum, plasma, and cell culture.

C-Reactive Protein (CRP) Assays: CRP is discussed as a marker for inflammation, with assays available for multiple species including canine, equine, feline, human, and others. The document emphasizes the role of CRP in the acute-phase response and its utility in assessing inflammation severity.

Immunoassay Applications: The assays are primarily for research use, with some registered for in vitro diagnostic use by the FDA and licensed by Health Canada. The document specifies the intended use and regulatory status of each product.

Data Summary: The tables in the document provide detailed specifications for each ELISA kit, including detection range, sensitivity, sample requirements, and incubation times.

Conclusion: This document serves as a comprehensive guide for selecting and using immunoassays in research and diagnostic settings, providing essential information on the performance and application of various ELISA kits.

Assay Specifications: The document lists numerous assays, including their catalog numbers, detection ranges, sensitivities, sample sizes, types, and incubation times. For example, the Serum Amyloid A ELISA has a range of 0.157–10 ng/mL with a sensitivity of 0.157 ng/mL, requiring a 10 µL sample of plasma or serum with a 1-hour incubation.

Key Biomarkers: The assays target various biomarkers such as Serum Amyloid P, ß Endorphin, Tri-CAT (Epinephrine, Norepinephrine, Dopamine), Tryptophan, Urocortin, Melatonin, and others. These biomarkers are crucial for understanding physiological and pathological processes.

Toxicology Insights: The document highlights the importance of identifying toxicological side effects in drug development, emphasizing hepatotoxicity, nephrotoxicity, and cardiotoxicity. It discusses the role of biomarkers like α-GST, NGAL, KIM-1, and Troponin I in detecting organ-specific injuries.

Flow Cytometry: ALPCO offers flow cytometry solutions for evaluating single-cell properties, with applications in molecular biology, pathology, immunology, and medicine. EuroFlow™ panels are available for immunophenotyping and identifying hematological malignancies.

Product Index and Ordering Information: The document lists various biochemical substances and their corresponding codes, such as Testosterone, Thyroglobulin, and Vitamin D, among others. Customers can set up an account on the ALPCO website to place orders, with payment methods including MasterCard, Visa, and American Express. Shipping charges are prepaid and added to the invoice, with standard overnight service used for most domestic shipments.

Catalog excerpts

ALPCO) ALPCO 26-G Keewaydin Drive Salem, NH 03079 Phone: 800-592-5726 Fax: 603-898-6854 [email protected] www.alpco.com ALPCOScientific Solutions for Life

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CVD & Oxidative Stress 023 Flow Cytometry 103 Diabetes & Obesity 033 Accessories & Equipment 121 American Laboratory Products Company (ALPCO) was founded in 1991 as an importer and distributor of immunoassay based products for the North American life science markets. Our origin began through an exclusive partnership with a European manufacturer, Buhlmann Laboratories, located just outside of Basel Switzerland. Over the past two decades, ALPCO has become a premier channel representing over 60 collaborating partners from around the globe. In late 2008, we launched our organically developed...

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Allergy & Infectious Disease Allergy & Infectious Disease Gastroenterology The immune system protects our body against several factors including allergens, harmful pathogens and foreign particles. Allergies involve an exaggerated response of the immune system and are among the most common chronic conditions worldwide. Infectious disease agents are also one of the leading contributors to debilitating and sometimes fatal conditions. Therefore, researchers and practitioners look to understand interactions between microbes and the immune system in order to 001 translate this knowledge into treatment,...

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FlowCAST® Basophil Activation Assays ALPCO is the exclusive distributor of BOHLMANN Laboratories' FlowCAST® allergy assays and allergens. FlowCAST® offers an easy, fast and reliable solution for allergy determination utilizing basophil activation measurement via flow cytometry. In vitro basophil activation testing reduces the risk of an anaphylactic event and patient discomfort while also providing a sensitive, quantitative measurement of non-IgE mediated reactions which serum IgE methods are unable to achieve. 003 Upon allergen contact, sensitized basophils degranulate and express the cell surface...

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Anti-Helicobacter Pylori IgG ELISA Anti-Helicobacter Pylori IgM ELISA Anti-Helicobacter Pylori Qualitative IgG ELISA Anti-Helicobactor Pylori ELISA Anti-Herpes-1 IgG ELISA 27-GD86 Anti-Herpes-1/2 IgM ELISA 27-GD88 Anti-Herpes-2 IgG ELISA 27-GD87 Anti-Ovalbumin IgA ELISA 27-GD40 Anti-Ovalbumin IgG ELISA 27-GD41 Anti-Ps-Aeruginosa IgA ELISA Anti-Ps-Aeruginosa IgG ELISA Anti-Rubella IgG ELISA 27-GD82 Anti-Rubella IgM ELISA 27-GD83 Anti-Soya IgA ELISA 27-GD44 Aspergillus IgG Antibody ELISA Bordetella Pertussis IgA ELISA Bordetella Pertussis IgG ELISA Bordetella Pertussis IgM ELISA (Leukotriene Function)...

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Allergy & Infectious Disease Description Catalog # FlowCAST Highsens® High Sensitivity Basophil Activation Test FlowCAST® Basophil Activation Test Herpes Simplex Virus 1 IgG ELISA Herpes Simplex Virus 1 IgM ELISA Herpes Simplex Virus 1/2 IgG ELISA Herpes Simplex Virus 1/2 IgM ELISA Herpes Simplex Virus 2 IgG ELISA Herpes Simplex Virus20 H2MHU Em 2 IgM ELISA20-H2MHU-E01 Histamine ELISA 17-HISHU-E01 Histamine ELISA Sensitivity Sample Size Sample Type Incubation See Protocol 100 pL Whole Blood 1h Description Catalog # Mumps IgG ELISA 20-MUGHU-E01 Mumps IgM ELISA 20-MUMHU-E01 Sensitivity...

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Allergy & Infectious Disease Gastroenterology Description Sample Size Sample Type Ureaplasma Urealyticum IgA ELISA Ureaplasma Urealyticum IgG ELISA Plasma, Serum Ureaplasma Urealyticum IgM ELISA Varicella Zoster IgA ELISA Varicella Zoster IgG ELISA Varicella Zoster IgM ELISA West Nile Virus IgG ELISA West Nile Virus IgM ELISA Mefenamic Acid Clavulanic Acid FDA Registered for In Vitro Diagnostic Use Catalog Number Products are for Research Use Only unless otherwise noted Visceral Leishmaniasis ELISA Health Canada Licensed Allergen Category Products are for Research Use Only unless otherwise noted...

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011 Allergen Category Sub-Category Description Catalog Number DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS DRUGS Proton Pump Inhibitors Rabeprazole 05-BAG2-CRAB Antibiotic Antibiotic Antibiotic Antiseptic Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Local Anesthetic Local Anesthetic Local Anesthetic Local Anesthetic Myorelaxant Myorelaxant Myorelaxant Myorelaxant Myorelaxant Myorelaxant Myorelaxant Myorelaxant Proton...

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013 Allergen Category Sub-Category Description Catalog Number FOOD FOOD FOOD FOOD FOOD FOOD FOOD FOOD FOOD FOOD FOOD FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES FOOD ADDITIVES INHALANTS Grass Bermuda Grass 05-BAG-G2 Milk/Milk Product Milk/Milk Product Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Seed/Bean/Nut Food Additive Food...

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Allergen Category 015 INSECT VENOMS RECOMBINANT ALLERGENS RECOMBINANT ALLERGENS RECOMBINANT ALLERGENS RECOMBINANT ALLERGENS ALLERGEN MIXES ALLERGEN MIXES ALLERGEN MIXES ALLERGEN MIXES ALLERGEN MIXES Insect Venom Recombinant Allergen Recombinant Allergen Recombinant Allergen Recombinant Allergen Allergen Mix Allergen Mix Allergen Mix Allergen Mix Allergen Mix Yellow Jacket Venom Check FEL D 1 (Cat Major Allergen) MAL D 1 (Apple Major Allergen) TRI A 12 (Wheat Profilin) ZEA M 12 (Maize Profilin) 6 Grass Mix (Orchard, Meadow fescue, Perenial rye, Timothy, Meadow, Velvet grass) Food Colorants I Mix...

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Bone Metabolism Bone Metabolism Bone metabolism is a continual, cyclic interplay of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. Disturbances to this delicate equilibrium, where reabsorption is greater than growth, can weaken the skeletal architecture and put one at risk for the development of chronic 017 and debilitating diseases such as osteoporosis. As we continue...

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