OSMOTIC PUMPS neuroscience research The blood-brain barrier (BBB) presents an impediment for effective delivery of agents to the central nervous system (CNS). For nearly 4 decades, ALZET® Osmotic Pumps have been used as a reliable and convenient tool to overcome the BBB and deliver agents directly to their site of action. These small, implantable pumps deliver a precise and continuous dose, without interference in elaborate behavioral testing, and without the stress associated with other methods requiring frequent animal handling. brain avoids many of the complications related to bioavailability, side effects, and toxicity inherent with systemic delivery. These pumps are now an integral component in neuroscience research, as evidenced by the thousands of publications describing their use in studies on spinal cord injury, neurodegeneration, ischemia, depression, brain cancer, and more. ALZET Pump Benefits • Direct delivery across the blood-brain barrier • Small size for implantation in mice or larger animals • Continuous and controlled delivery of neuroactive agents • Ideal for behavioral studies - no animal handling required during dosing • Improved bioavailability of short half-life peptides and proteins • Easy attachment to a catheter for delivery to the brain, spinal cord or peripheral nerves • Reliable technology with over 15,500 publications • Reduced drug toxicity and side effects • Simple design and easy to use • Convenient and cost-effective for chronic dosing of lab animals • Automatic nighttime and weekend dosing • Improved animal welfare

Neuroscience Research Applications Models of Neurodegenerative disease ALZET pumps have been used to facilitate the development of animal models of neurodegenerative disease, including Alzheimer's, Parkinson's and Huntington's. Their ability to provide a slow, continuous and chronic dose is favorable for sustaining a stable disease state over prolonged periods. In vivo models of Parkinson's have been produced by continuous administration of 6-hydroxydopamine (6-OHDA) into the striatum of rats, systemic infusion of the neurotoxin MPTP to mice or monkeys, and systemic rotenone dosing in rats. A...

Neuroscience Research Publications Therapeutic antibodies, enzyme inhibitors, antidepressants, anticonvulsants, dopaminergics, opioids, neuropeptides, neurotrophic factors, and nucleic acids are all examples of agents that have been successfully delivered via ALZET pumps. Below is a list of agents recently added to the ALZET bibliography. Protein kinase C inhibitor Catecholamine release inhibitor Glycoside antiprion compound Prolyl oligopeptidase inhibitor Pramlintide acetate Synthetic amylin analogue Synthetic guanylhydrazone mitogen-activated protein kinase blocker Tankyrase inhibitor; Wnt/β-catenin...

ALZET Products for Neuroscientists ALZET Osmotic Pumps Brain Infusion Kits Twelve pump models available in 3 different sizes, durations ranging from 1 day to 6 weeks, and various release rates. Designed for use with ALZET pumps, they are ideal for delivery to lateral ventricles and other brain regions in rats (BIK1 & 2) and mice (BIK3). Rat & Mouse Intrathecal Catheters Cannula Holders Designed to hold the removable tab on all ALZET brain cannulae, they facilitate stereotaxic placement of brain cannula to the skull of lab animals. These are constructed with high quality materials for increased...