ALZET Applications in Translational Research • Pharmacokinetic studies • In vivo drug efficacy • Drug safety and tolerability • Dose escalation studies • Maximum starting dose estimation • Evaluation of optimal dosing schedules cazsf OSMOTIC PUMPS Translational research is a bi-directional process in which scientific knowledge is used to direct clinical development and clinical knowledge used to drive basic research. This strategy aims to accelerate the pace at which novel research discoveries are translated into safe and effective clinical therapies. Effective translation of therapeutic strategies from the experimental phase into the clinic is often dependent on the availability of suitable animal models that closely mimic clinical features. Equally important is the use of reliable research tools to ensure reproducible study results. ALZET Osmotic Pumps are useful drug delivery tools for translational research and drug development. These small infusion pumps have been used in translational research studies designed to evaluate drug pharmacokinetics, safety and tolerability. They are also used in dose escalation studies designed to determine the maximum starting dose or effective therapeutic dose. Compared to conventional dosing methods, ALZET pumps allow greater control and accuracy in drug delivery, thus reducing dosing errors, ensuring stable dose levels and minimizing adverse effects. Most importantly, they help generate reliable preclinical data that can then be applied to clinical studies with greater confidence. Listed below are two case studies describing the use of ALZET pumps in translational research. Additional references are available from ALZET Technical Services at 800.692.2990 or [email protected]. DURECT Corporation | 10260 Bubb Road | Cupertino CA, 95014 T: 408.367.4036 F: 408.865.1406 Toll Free 800.692.2990 WWW.ALZET.COM | [email protected]

Translational Research ALZET Research Application dzef OSMOTIC PUMPS DURECT Corporation | 10260 Bubb Road | Cupertino CA, 95014 T: 408.367.4036 F: 408.865.1406 TOLL FREE 800.692.2990 WWW.AIZFT.COM |