Scientific CMOS Zyla and Neo sCMOS Cameras Widen Your Expectations Introducing the Zyla 4.2 PLUS • 82% QEmax • 99.8% linearity • 53 fps (USB 3.0) • 100 fps (Camera

Scientific CMOS (sCMOS) technology overview sCMOS - Imaging without compromise Scientific CMOS (sCMOS) is a breakthrough technology that offers an advanced set of performance features that render it ideal to high fidelity, quantitative scientific measurement. Scientific CMOS can be considered unique in its ability to simultaneously deliver on many key performance parameters, overcoming the ‘mutual exclusivity’ associated with current scientific imaging technology standards, and eradicating the performance drawbacks traditionally associated with CMOS imagers. sCMOS is uniquely capable of simultaneously...

Minimization of dark current to maintain low noise advantage under all exposure conditions. Minimization of hot pixel blemishes meaning more useful pixels. Fan-off mode for vibration sensitive set-ups. Rolling and true Global (Snapshot) shutter Maximum exposure and readout flexibility across all applications. Snapshot for ‘Interline CCD’ Offers lower detection limit than any CCD. 5.5 megapixel sensor format and 6.5 μm pixels Delivers extremely sharp resolution over a 22 mm diagonal field of view: ideal for cell microscopy, digital pathology, high content screening and astronomy. Dark Noise Suppression...

Features and Benefits Compact and light Rolling and true Global (Snapshot) shutter Andor’s Zyla 5.5 sCMOS camera offers high speed, high sensitivity imaging in a remarkably light and compact design. Both Rolling and true Global shutter modes offer extensive application flexibility. Global shutter is ideally suited to fast multi-dimensional microscopy, offering tight synchronization to ‘moving’ peripheral devices such as z-stage or light source. 100 fps sustained via Camera Link (full frame). Industry fastest USB 3.0 frame rates. Offers a market-leading speed of 27,057 fps from a 2560(h) x 8(v)...

Highest available photon capture efficiency across visible/NIR, optimized for all common fluorophores. Lowest read noise sCMOS. Significantly lower than any CCD. Market leading USB 3.0 speed Superb USB 3.0 data transfer efficiency and Zyla’s unique 12-bit high speed mode deliver up to 53 fps full resolution, 77% faster than competing sCMOS. Follow dynamic processes with improved temporal resolution. Offers a market-leading speed of 26,041 fps from a 2048(h) x 8(v) region of interest, ideally matched to the temporal demands associated with Fluorescence Correlation Spectroscopy. LightScan PLUS...

Zyla - The Biologist’s Choice Zyla sCMOS has proven a superb camera choice for the biologist and microscopist. Many simply see the Zyla as an amazing value, superb price/performance ‘workhorse’ camera with which to replace their existing Interline CCD and upgrade the performance of their fluorescence microscope. Others are driven by distinct application performance criteria that only sCMOS can answer. Quality, Throughput, Performance, Accessibility… • High Sensitivity and Wide Dynamic Range – quantify very weak and very bright structures with one image. • Superb Image Quality – high resolution...

Upgrade Your Microscope’s Performance Why is Zyla such an impressive all-round imager? Zyla sCMOS - Disruptive Technology, Familiar Price • Superior performance – vastly superior to Interline across key performance parameters. • Rolling and Global exposures (Zyla 5.5) – Zyla is unique in offering both these exposure modes in one camera. Global shutter (Snapshot) is directly analogous to the Interline exposure mechanism. • Image quality – a huge amount of effort and on-camera (FPGA) intelligence has gone into optimizing image quality in Zyla. What was the benchmark imaging detector? Interline...

Performance and Innovations Extended Dynamic Range The Andor Neo and Zyla cameras are designed to make use of the innovative dual ‘column-level’ amplifier design of the sensors. Traditionally, sensors require that the user must select up-front between high or low amplifier gain (i.e. sensitivity) settings, depending on whether they want to optimize for low noise or maximum well depth. The dual amplifier architecture of the sCMOS sensor circumvents this need, in that signal can be sampled simultaneously by both high and low gain amplifiers. As such, the lowest noise of the chip can be harnessed...

Data Flow Monitor Rapid Frame Rates The parallel readout nature of sCMOS means it is capable of reaching very rapid frame rates of up to 100 full frames per second, and much faster with region of interest. Distinctively, this is accomplished without significantly sacrificing read noise performance, markedly distinguishing the technology from CCDs. Andor’s sCMOS cameras are uniquely designed to harness this speed potential. Array Size Rolling shutter For sustained kinetic series measurements it is possible to be rate limited by: Global shutter Rolling shutter Rolling shutter Rolling shutter Global...

UltraVac™ (Neo only) The Andor Neo is the only vacuum housed CMOS sensor available on the market, offering superior quality, performance and longevity. Deep Thermoelectric Cooling Andor’s Neo offers the deepest sensor cooling available from any CMOS imaging camera on the market, minimizing both dark current and hot pixel blemishes. Additionally, through the use of water cooling, the fan can be switched off in the software to minimize camera vibration; ideal for set-ups that are particularly vibration sensitive. Neo Cooling Temperature Dark current (e /pix/sec) Andor’s proprietary UltraVac™ process...

Large Field of View Advanced FPGA on-head processing Andor’s Neo and Zyla cameras are each equipped with considerable FPGA processing power. This is essential in order to dynamically normalize data at the pixel level for minor variations in bias offset, thus eradicating fixed pattern noise associated with this CMOS phenomenon. This superior dynamic processing capability is also utilized to optionally filter the small percentage of spurious noise pixels from the image. The multi-megapixel sensors present in the Neo and Zyla offer an extended field of view, markedly exceeding the FOV available...