Cingal®

Cingal®

Cingal®

Product catalog summary
Overview: Cingal® is a one-injection combination treatment for osteoarthritis (OA) knee pain, combining hyaluronic acid (HA) and triamcinolone hexacetonide (TH). It offers fast-acting and long-lasting pain relief, with clinical data supporting its efficacy and safety.
Specifications: Cingal® is designed as a viscoelastic supplement or replacement for synovial fluid in knee joints. It provides lubrication and mechanical support for long-term symptom relief, supplemented by short-term pain relief from TH.
Clinical Efficacy: Cingal® has shown significant pain reduction at weeks 11 and 26, with responder rates of 92% in clinical trials. It is more effective than other OA pain management injections.
Mechanism of Action: HA in Cingal® binds to water, providing lubrication and acting as a shock absorber. It also has chondroprotective and analgesic effects, reducing nerve impulses and sensitivity. TH offers rapid anti-inflammatory effects.
Clinical Trials: Three Phase III trials (Cingal 13-011, 16-025, 19-016) demonstrated consistent responder rates of over 90% at 26 weeks.
Product Benefits: Cingal® combines the benefits of HA and TH, offering a chondroprotective effect and reducing side effects associated with steroids alone.
Market Presence: Since its launch, nearly 1 million injections have been administered in over 35 countries outside the U.S.
Recommendations: Cingal® is recommended for patients seeking rapid and sustained relief from chronic knee pain due to OA.
Contact Information: Anika Therapeutics, Inc., 32 Wiggins Ave., Bedford, MA 01730 USA. Email: [email protected]. Website: www.anika.com.
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Catalog excerpts

Cingal®-1

One-Injection Combination Hyaluronic Acid and Triamcinolone Hexacetonide Product Brochure 59% Pain Reduction at Week 11 72% Pain Reduction at Week 261 92% Responder Rate at Week 261 The most powerful next-generation OA pain management treatment available 1,2 For chronic pain associated with osteoarthritis of the knee

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Cingal®-2

One-Injection Combination Hyaluronic Acid and Triamcinolone Hexacetonide For patients who demand rapid and tong-tasting relief from chronic knee pain associated with OA, there is one treatment that surpasses att others.2 Anika's Market-Leading Safe and Proven Triamcinolone Hexacetonide (TH) Steroid Micronised TH steroid uniformly suspended within a high-dose, ultra-pure and lightly cross-linked HA4 Unmatched clinical data proving Cingal's efficacy Cingat is supported by robust ctinicat data, consistentty proving efficacy and safety, and stronger in terms of pain retief than any other OA pain...

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Cingal®-3

Anika’s market-leading HA is designed to mimic the molecular properties of endogenous HA7 Mechanical effect Chondroprotective effect Analgesic effect HA binds well to water, producing a viscous, jelly-like consistency that provides lubrication and acts as a shock absorber within the joint. HA has a biomechanical structure that protects cartliage when surrounding chondrocytes. HA diminishes nerve impulses and the sensitivity of nociceptive nerve endings. TH directly treats inflammation in the joint, providing fast-acting pain relief within days of injection1 FAST ACTING LONG LASTING Pain reduction...

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Cingal®-4

Cingal® Optimal high molecular weight HA Results in greater pain reduction and longer duration of effect than low molecular weight or excessively high molecular weight HA.10 Optimal Binding Affinity Steric Hindrance Limited stimulation of biosynthesis of HA Limited stimulation of biosynthesis of HA CINGAL MONOVISC Indications Cingal® is indicated as a viscoelastic supplement or a replacement for synovial fluid in human knee joints. Cingal® is well suited for rapid and long-term relief of the symptoms of human knee joint dysfunctions such as osteoarthritis. The actions of Cingal® are long-term...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.