Hyaluronic Acid Single Injection Product Brochure Long-lasting knee pain relief The market-leading single injection viscosupplement utilised to treat joint pain caused by osteoarthritis.

Hyaluronic Acid Single Injection is a single high dose viscosupplement injection approved for the treatment of OA in the knee joint1 Lightly Cross-Linked Monovisc is a sodium hyaluronate injection that is lightly cross-linked to increase residence time in the knee13 Non-Avian HA Monovisc is manufactured from ultra pure, high molecular weight sodium hyaluronate produced by bacterial fermentation1 #1 U.S. Viscosupplements Monovisc is FDA approved and as a viscosupplement franchise, Monovisc & Orthovisc are the most prescribed in the United States4 Up to 39 weeks of clinically proven efficacy with...

Monovisc is formulated to mimic the properties of endogenous HA6,7 In human joints, endogenous HA is present in the cartilage extracellular matrix and synovial fluid and has several functions, including: Mechanical effect Anti-inflammatory effect HA binds well to water, producing a viscous, jelly-like consistency that provides lubrication and acts as a shock absorber within the joint. HA plays an important role in reducing joint inflammation and pain caused by injury or tissue degeneration.7,8 Analgesic effect Chondroprotective effect HA diminishes nerve impulses and the sensitivity of nociceptive...

Monovisc™ Clinically proven long lasting pain relief through 6 months13,14 • Monovisc delivers a 65% improvement in WOMAC pain at week 26 relative to baseline (p = 0.0352)*,13 Monovisc delivers an 85% responder rate in the OMERACT-OARSI Responder Index through 26 weeks*,14 Monovisc patients experienced a clinically meaningful reduction in OA knee pain within 2 weeks of their injection**,15 *Study design: The referenced clinical study was a randomized, double-blind, saline-controlled, three-arm, multicenter clinical trial. A total of 368 patients with knee osteoarthritis (KL grades I-III) were...