Hyaluronic Acid Multi-Injection Product Brochure Less pain & improved mobility after just Effective OA pain relief whilst reducing the use of prescription pain medication The multi-injection viscosupplement provides up to six months of joint pain relief whilst reducing the use of prescription pain medications such as steroids, NSAIDs, and opioids.3

Hyaluronic Acid Multi-Injection Orthovisc is an ultra-pure, high molecular weight injectable hyaluronic acid (HA) viscosupplement used to treat the symptoms of osteoarthritis.4 Less pain and improved mobility after just 3 injections • • • • Pain relief within 1 week of injection1 Pain relief for up to 6 months1 Reduced risk of reactions1 May delay total joint replacement surgery for an average of 3.6 years5 When injected directly into the joint space, Orthovisc lubricates, cushions, and protects, bringing pain relief that lasts up to 6 months. Clinical evidence Average change in WOMAC® pain score...

Reduced use of prescription painkillers and steroid injections A retrospective study of nearly 30,000 patients demonstrates that Orthovisc offers effective pain alleviation among knee OA patients whilst reducing the use of prescription pain medications such as steroids, NSAIDs, and opioids.3 6-months post-injection results, statistically significant: • Reduction in the use of NSAIDs and steroids • Reduction in the proportion of patients filling prescriptions • Reduction in the number of patients getting opioid prescriptions Average number of steroid injection prescriptions were reduced by Optimal...

Orthovisc® Indications Orthovisc is indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints. Orthovisc is well suited to provide relief for the pain of osteoarthritis. The actions of Orthovisc are lubrication and mechanical support.8 Directions for use8 The required amount of Orthovisc is slowly infused through a sterile, disposable, ISO/ANSI-conforming, non-rigid hubbed hypodermic needle of suitable gauge into the selected joint space. Common needle gauges for injections into the knee are 18-21 gauge. The final needle selection for any procedure is determined...