Hemorheology Test Assessment of Deformability, Aggregation, and Critical Shear Stress of RBCs Innovative technology of diabetic complication screening assay 2F., 32, Anam-ro, Dongdaemun-gu, Seoul, 02578, Republic of Korea TEL +82-2-537-5111, +82-2-537-5102 FAX +82-2-537-5103 E-mail [email protected] / [email protected] Website www.any-sis.com / www.rheoscan.com Innovation Diagnostic POCT RheoScan In Healthcare Screening device Point of Care Technology Early detection of diabetic complications

Global impact of Diabetic Complications Diabetes is a condition in which blood sugar is too high, which interferes with the flow of blood, causing several complications. Fatal diabetic complications, such as blindness, foot necrosis, and kidney failure, can also lead to death if not properly treated. Diabetic Complications It is highly important to screen before symptoms occur. Early detection, timely treatment, appropriate follow-up care can reduce the risk of severe symptoms . Diabetic Kidney Disease (DKD) The kidneys are blood vessels in which capillaries are intertwined. 20 ~ 40% of diabetic...

RheoSCAN as a Point of Care Technology The best treatment starts with early detection RheoScan Measures Associated Pathologies - Diabetic Kidney Disease - Diabetic Retinopathy - Metabolic Syndrome RheoSCAN system Diabetes Mellitus Elevated Fibrinogen Normal RBCs : highly deformable Impaired RBC Deformability leads to hypoxia Hardened RBCs : less deformable RBC deformability plays a critical role in blood circulation. Healthy RBCs have to pass through capillaries whose diameter is smaller than their size. Decreased red blood cell deformability results in hypoxia due to decreased oxygen delivery...

RheoSCAN system Clinical Test RBC Deformability Diabetic complications have been reported to significantly decrease in RBC deformability compared to the healthy group. RBC Aggregation Deformability vs. ACR-classfied DKD CSS vs. ACR-classfied DKD 350 DM complication shows significantly elevated RBC aggregation compared to healthy controls and Pre-DM groups. Critical shear stress (CSS) Sensitivity Diagnosis of DKD with Deformability Diagnosis of DKD with CSS Deformability vs. Glycated Hemoglobin (HbA1c) O Control • DM □ DM+CRF ■ DM+ESRD A DMR A DMR+DMN Critical shear stress (mPa) 800 600 HbAlc(%)...

I Microfluidics and laser optics meet Hemorheolgy The Rheoscan System is an innovative technology to measure RBC deformability and aggregation with adopting leading-edge microfluidics and laser optics. DEFORMABILITY Microfluidics / Laser-diffractions / Image-processing AGGREGATION - I (CSS) Microfluidic Shearing / Light Backscattering / Data-processing AGGREGATION - II Microfluidic Stirring / Light Transmission / Data-processing DEFORMABILITY (EI) • A blood sample is driven by a vacuum pressure, which is automatically decreasing with time. • While the sample flow through a microchannel, laser...

RheoMeditech Inc. is a leading manufacturer of wide range of in vitro diagnostic analyzers, test kits, and consumables. Our line of instruments and test kits are specially designed to elevate the best performance to hospitals and laboratories. RheoMeditech offers early screening and diagnostics that provide health care professionals to make better decisions. With greater trust, we can help people achieve better health through our early diagnosis systems with innovative technology. The best treatment starts with early detection. 1. Chung et al., Critical Shear Stress is Associatedwith Diabetic...