THE FLEXIBLE AND AUTOMATABLE SYSTEM SOLUTION FOR BIOBANKING
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THE FLEXIBLE AND AUTOMATABLE SYSTEM SOLUTION FOR BIOBANKING - 1

THE FLEXIBLE AND AUTOMATABLE SYSTEM SOLUTION FOR BIOBANKING Freezing * Storage * Automation * Transportation ASKION C-llne»*

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B Biobanks are a basic requirement for research and therapy. BIOBANKS/CRYO STORAGE INTRODUCTION In March 2009 the Time Magazine described under the title '10 Ideas that are changing the World' biobanks as instruments of science that will revolutionize modern medicine (Time Magazine March 23. 2009 I Vol. 173 No. 11). Biobanks provide basic data for the development of new cancer therapies and the research of biomarkers and they are a basic requirement for promising cell therapy, too. In addition to the growing number of stored samples their quality and logistical availability after decades of...

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After the samples had been frozen in the best possible way they should be handled as cold as possible to avoid sample damaging processes, e. g. migratory crystal growth, by repeating warm-up and freezing cycles, The question now is which temperature is the best to handle frozen samples. DThe best handling temperature for frozen samples is below-100-C. Experiments had been used to determine a handling temperature of at least -100'C for frozen samples as the best (Germann et al. 2013). At this temperature frozen samples can be handled without any significant loss in sample quality. This...

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CRYOGENIC STORAGE FOR BEST POSSIBLE SAMPLE QUALITY PRESERVATION OF SAMPLE QUALITY For preservation of sample quality, sample damaging processes, as migratory crystal growth, have to be avoided During these processes smaller crystals of the freezing medium transform to bigger crystals and the surface energy will be reduced. These thermodynamically driven processes come to a standstill starting below -130'C. For this reason the sample storage should take place at temperatures below -150'C to ensure the remaining of the sample quality for the whole storage period. Another reason for the...

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MAXIMUM FLEXIBILITY FOR THE OPERATION OF A BIOBANK Picture of a tray (storage place of samples) of the ASKION C-line' hermetic storage that can be adapted to the particular sample format according to operator needs The ASKION C-line’ system is structured similar to a building kit. According to operator needs it is possible to prepare an individual, customized solution (for example with regard to sample formats). I ASKION C-line* system is a modular and flexible building kit with four main components: > ASKION C-line' hermetic storage > ASKION C-line* work bench > ASKION C-line' automation »...

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FREEZING PROCESSESEXACT AND REPRODUCIBLE FREEZING ENABLES PRESICE CONTROL AND COMPARABILITY The ASKION C-line* work bench allows freezing of different sample types and formats defined and reproducible by measuring the sample temperature with a reference sensor. I ASKION C line' work bench > Defined and reproducible freezing > Sample format independent > High accurate freezing by measuring sample temperature »Automated parameter recording for each sample (documentation) > Multiple freezing processes in parallel > 10/20 barcode scanner > SBS rack scanning down to below -130*C Exemplary...

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EASIER ACCREDITATION SECURED AND COMPLETE DOCUMENTATION By simultaneously recording of all parameters and processes for every single sample the complete and precise documentation is guaranteed (further information in section ASKION C-line' control, page 22). These data files can be evaluated directly with the control software ASKION C-line‘ control or optionally retrieved by an interface to the existing IT infrastructure (e. g. UNIS). The ASKION C-lme' system meets all requirements on a biobank system for maximum sample quality and safety, user-friendliness and documentation: > Fully...

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★ ASKION C-line hermetic storage MODULARITY AND INDIVIDUALIZATION AT ANY POINT IN TIME The ASKION C-line' hermetic storage (HS200) is a highly efficient, fully automatable system for cryogenic storage of all types of biomaterial. Since 2008 and meanwhile in the second generation is the HS200 the heart of the ASKION C-line* system for sample storage at highest quality. The samples are stored in the gas phase of liquid nitrogen at storage temperatures down to -185‘C. HS200 M/L Sample storage down to -185*C Sample handling below -130*C Cherry picking robot SBS Rack handling robot Fully...

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★ ASKION C-line hermetic storage IHS200 S > Sample storage down to -185*C > Sample handling below-110'C * Cherry picking robot (optional) * Fully automatable biobank (optional) > 1D/2D barcode scanner > Uninterrupted cooling chain > Up to 79,000 vials per HS The HS200 consists of two main components, the nitrogen storage tank with storage racks for samples and the patented upper hermetic hood construction at which the sample handling during storage and retrieval takes place at cryogenic temperatures. ASKION C-lir>e* hermetic storage HS200 S Inside the nitrogen tank the samples are stored at...

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The upper hood construction enables to restore samples at temperatures down to below -130'C. Depending on the chosen level of automation the storage process will be performed either manually or automated as single sample handling or in SBS racks. I> Stepwise automatable (also in field) > Retrofittable automation tools * Automated SBS rack and single tube handling * Sample handling down to below -130'C > Automated recording of all parameters for each sample and system GMP COMPLIANT WORKINGAUTOMATED AND COMPLETE DOCUMENTATION FOR EACH SINGLE SAMPLE The HS200 provides an internal barcode...

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★ ASKION C-line automation INCREASED HANDLING SAFETY AND SAMPLE THROUGHPUT With an increasing number of samples the challenges for sample handling increase significantly. This includes both, sample data management (currently often manually by lists) and the actual sample handling (e. g. manual lifting of storage racks out of a nitrogen drum, pulling out a box and pick-up of one or several samples). B> Automated SBS rack and single tube handling * Sample handling at environmental temperatures down to below -130'C > Ergonomic and safe operation In many laboratories nitrogen storage systems...

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