HbA1c
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HbA1c Monitoring of glycaemic control

Glycated haemoglobin, or HbAlc, is formed by the reaction of glucose with normal haemoglobin (Hb). The amount of glycated haemoglobin (HbA1c) in red blood cells therefore increases with the average blood glucose concentration. Because the lifespan of a red blood cell is typically 100-120 days, HbA1c levels provide an accurate estimate of control of glucose levels over the previous 2-3 months. Poor control of blood glucose levels is directly linked to the risk of development and progression of the chronic complications of diabetes(l) High blood glucose levels (hyperglycaemia) can be a severe...

Axis-Shield HbA1c Assay The Axis-Shield HbA1c reagents provide a highly accurate and precise method for the quantitative determination of % HbA1c in whole blood and are simple to use on any clinical chemistry instrument: Precision Three human whole blood samples were tested in duplicate twice per day for 20 days: Sample Accuracy Whole blood samples were tested in the Axis-Shield assay and a Capillary Electrophoresis (CE) method: Interference Samples containing Haemoglobin variants A2, S, C, D, E and F have all been tested and show no significant interference in the Axis-Shield assay:...

The Axis-Shield HbAlc assay offers a number of convenient features making it suitable for use on any chemistry analyser: Part Number Description 2 levels, I mL of each Lyophilised 5 levels, I mL each Lyophilised * dependent on instrument protocol volumes 1. DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329(14):977-86. 2. Lester E. The clinical value of glycated haemoglobin and glycated plasma proteins. Ann Clin Biochem 1989;26:213-9. 3. Goldstein...