Exceptional Performance and Ease of Placement Long-Term Dialysis Catheter has joined BD

SIMULATED FLOW PERFORMANCE Lower PressuresLower is Better GlidePath® catheters demonstrated on average 15% higher flow rates in forward and reverse flow compared to Palindrome™ Precision catheters1 GlidePath® catheters demonstrated on average 16% lower pressures in the arterial lumen compared to Palindrome™ Precision catheters1 Blood Simulant1At Max Arterial Pressure (-250 mmHg)11 600 ro 400 200 Catheter Precision Catheter Catheter Precision Catheter Forward Reverse to 3 O Catheter Precision Catheter Catheter Precision Catheter 23 cm catheters111 .2 'Z a> < 300 (ml/min) Flow 11 400 (ml/min) Flow...

Computational Fluid Dynamic Model Flow Performance And Lumen Design Lumen Design is the Difference Lumen Designed to Minimize Deflection Under Pressure to Improve Flow Performance -13 % Pinched Lumen Corners May Impact Flow Performance Computational Model of Arterial and Venous flow streams at 300ml/min -Forward Flow 11 Excellent Recirculation Rates 1% or Less on Average in Both Forward and Reverse1 Improved Inner Lumen Design Represents catheter lumen wall and septum deflection when flowing at 400ml/min and at max. allowable arterial pressure (when -250mm Hg is reached per KDOQI Standard). Fluid...

FLOW-PRESSURE PERFORMANCE Flow-Pressure Under Partial Occlusion Lower Pressure is Better GLIDEPATH® catheters demonstrated on average 16% lower arterial pressures compared to Palindrome™ Precision catheters‡ Average Pressure (mmHg) Blood Simulant* Average Pressure (mmHg) G P Palindrome Catheter Precision Catheter Palindrome™ G P Catheter Precision Catheter 300 (ml/min) Flow‡‡ Forward 23 cm catheters‡‡‡ 300 (ml/min) Flow‡‡ Reverse Arterial Side of the Catheter Tip Forced Against the Tube Wall During Flow Bench data on file. May not necessarily correlate to clinical performance. Groups found to...

GlidePath Long-Term Dialysis Catheter One Pre-Loaded Stylet to Simplify Over-the-Wire Placement* Smooth Tapered Tip and Tapered Cufffor Easy Insertion AirGuard® Valved Introducer Reduces Risk of Air Embolism Integrated Valve AirGuard® Valved Introducer Fixed Suture Wings Provide Stability Tapered Cuff Thermosensitive Polyurethane Shaft SureCuff® Tissue In-Growth Cuff Catheter Size Introducer Size GlidePath® Catheter Palindrome™ Precision Catheter ‘Straight codes only Tip Designed to Resist Positional Occlusion Symmetric Tip Design

SURFACE ROUGHNESS Front Openings1 Surface is Better SEM Images**** Palindrome™ Precision Average 0.962(gm) Side Holes1 Smoother Surface is Better GlidePath® Median 0.506(gm) Representative Images * Optical Profilometry tested using Zygo Optical System on the edges of the distal tip features, N=20 per group, GlidePath® and Palindrome™ Precision. * 1 Groups found to be statistically different using an unstacked ANOVAwith p-value less than 0.05 at 95% confidence (0.000 for all comparative groups). Calculation of at least 2X smoother based upon the ratios of mean surface roughness values. * 11 Groupsfoundtobe...

Kink Diameter* Smaller Kink Diameter is Better The GlidePath® catheter shaft demonstrated on average up to 7% smaller kink diameter values when compared to the Palindrome™ Precision catheters** Kink Diameter= Furthest Distance Achieved Before Kink Occurs Kink Diameter * Tested using catheter shafts from 23cmtiptocuff straight catheters (GlidePath n=20, Palindrome Precision n=20) * * Groups found to be statistically different using an Unstacked ANOVAwith p-value less than 0.05 at 95% confidence (0.000 for all comparative groups). Calculation based upon the ratios of average kink diameter values....

Ordering Information GlidePath® Catheters - Straight GlidePath® Catheters - Alphacurve® Catheter Tip to Cuff Tip to Hub Standard Kit Length Length Product Codes GlidePath® Catheters - Straight 14.5 Fr Catheter 15 Fr AirGuard® Valved Introducer with Peel-Away Sheath/ Dilator 10 - 12 Fr Dualator® Dilator Insertion Stylet Tunneler 2 End Caps ID Card IFU Introducer with Peel-Away Sheath/ j • 18 Gauge Introducer Needle i • 2 Adhesive Dressings • ID Card • IFU GlidePath® Catheters - Alphacurve® Catheter Standard Kit Contents The Alphacurve® Catheter Standard Kit comes with the same contents as the...