MPO Test Kit (FIA) 00027C

Product catalog summary

Overview of Myeloperoxidase (MPO) Enzyme:
Myeloperoxidase (MPO) is an enzyme located in neutrophil primary granules and monocyte lysosomes. It catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. The enzyme is encoded by a single gene and undergoes posttranslational modification to become active in leukocytes. Autoantibodies to MPO, known as MPO ANCA, are associated with several diseases, including microscopic polyangiitis (MPA), and may contribute to vascular inflammation.

Clinical Significance of MPO ANCA:
MPO ANCA is commonly found in patients with MPA, who may present with azotemia due to glomerulonephritis. These autoantibodies are not exclusive to MPA and can also be detected in systemic lupus erythematosus, Goodpasture syndrome, and Churg-Strauss syndrome. Autoantibody testing is crucial for distinguishing these conditions, as clinical signs and symptoms alone are insufficient.

Test Kit Specifications:
The MPO Test Kit is designed for whole blood, serum, or plasma samples with a volume of 75μL. The assay time is 15 minutes, with a working range of 10-1000 ng/mL and a performance coefficient of variation (CV) of ≤15%. The kit should be stored at temperatures between 2-30℃ and has a shelf life of 12 months.

Ordering and Contact Information:
The MPO Test Kit (Cat #00027C) is available in packs of 25 tests per box, with 20 boxes per carton. It is compatible with KS-001 and KS-002 Dry Fluorescent Immunoassay Analyzers. For orders, contact Beijing O&D Biotech Co., Ltd. via their website or through representatives Grace Zhang and Jason Du.

Compatible Instruments:
The KS-001 and KS-002 analyzers are compatible with the MPO Test Kit. KS-001 is a single-channel analyzer, while KS-002 is a 12-channel analyzer. Both have a CV of ≤10% and feature built-in thermal printers.

Technical Strengths:
The test utilizes semi-liquid phase reaction and red nanofluorescent microsphere technology, enhancing sensitivity and accuracy. This technology minimizes interference from endogenous fluorescent substances and maintains stable fluorescence under light exposure.

Additional Test Parameters:
The document also lists various other tests available from O&D Biotech, including cardiac markers, diabetes-related tests, hormone levels, and infection markers, each with specific sample types, volumes, assay times, and clinical references.

Catalog excerpts

Myeloperoxidase (MPO) enzyme is found in neutrophil primary granules and monocyte lysosomes. MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes. Autoantibodies to MPO (MPO antineutrophil cytoplasmic antibodies: ANCA) occur in several diseases and may be involved in the pathogenesis of vascular inflammation in patients with microscopic polyangiitis (MPA). Patients with MPA often develop MPO ANCA and may present with azotemia secondary to glomerulonephritis (pauci-immune necrotizing glomerulonephritis). MPO ANCA are not specific for MPA, and also may be detected in patients with systemic lupus erythematosus with or without lupus nephritis, Goodpasture syndrome and Churg-Strauss syndrome. Lupus nephritis and Goodpasture syndrome, as well as Wegener granulomatosis may present with azotemia and progressive renal failure. It is not possible to distinguish among these diseases on the basis of clinical signs and symptoms; autoantibody testing may be helpful. Test cassette Extraction buffer

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Specification Sample type Sample vol. Assay time Working range Performance Storage Shelf Life Ordering Information Item Myeloperoxidase (MPO) Test Kit Packing 25 tests/box; 20 boxes/ctn Beijing O&D Biotech Co., Ltd. Web: www.odbio.com Contact: Grace Zhang, [email protected]; Jason Du, [email protected] ADD: West, Floor 4, Building 1, No.1, Shunqiang Road, Renhe Town, Shunyi District, Beijing, Chi

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Compatible Instruments Specifications Item KS-001 Dry Fluorescent Immunoassay Analyzer KS-002 Dry Fluorescent Immunoassay Analyzer Catalogue Number Testing Modes Auto-test/Queuing/Instant test Automatic testing Testing Speed 120 T/h under the Queuing Mode 8" LCD screen. The instrument can be connected to a monitor by VGA interface. Built-in thermal printer Built-in thermal printer

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Technical Strength 1. Semi-Liquid Phase Reaction Half of the immune reaction is done in the liquid phase, which effectively improves the sensitivity and accuracy of the product. In the sample, the antigen binds more fully to the fluorescently labeled antibody. The release of fluorescent microspheres on the NC membrane is more uniform. Test results of whole blood samples have better repeatability. 2. Red Nanofluorescent Technology a. Comparing with ordinary fluorescein 1) FITC (fluorescein isothiocyanate) and other fluorescent substances are light sensitive and thus easily quenched. Their fluorescence...

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