Innovating future life. Hyaluronic Acid Therapy www.bioceramed.com bioceramed

Key Mechanisms of Hyaluronic Acid in Osteoarthritis Improved Lubrication Hyaluronic acid significantly enhances joint lubrication, reducing friction and wear during movement, which in turn helps relieve pain. Natural Stimulation of HA Synthesis Hyaluronic acid (HA) stimulates the body to produce its own hyaluronic acid, promoting joint health and maintaining homeostasis (1) in the synovial fluid. Inflammation Reduction By binding to CD44 receptors in the cells, hyaluronic acid (HA) supports the production of extracellular matrix components (2) and inhibits inflammatory responses, contributing to...

Key Mechanisms of Hyaluronic Acid in Osteoarthritis Reduction of Nerve Sensitivity Hyaluronic acid (HA) helps reduce hypersensitivity (3) of the nerves involved in pain transmission, providing relief from discomfort associated with osteoarthritis. Reduction of Inflammatory Mediators Hyaluronic acid (HA) reduces the production and activity of pro-inflammatory mediators (4), further contributing to inflammation and pain control in patients with osteoarthrit

Safety and Precautions Contraindications Healvisco products are not suitable for patients with hypersensitivity to any of their components. Risk of Infection These products should be avoided in cases of septic arthritis or any skin condition at the application site, to prevent potential complications. Special Populations Healvisco is not recommended for children, pregnant women, or breastfeeding women due to insufficient clinical data on its safety. Precautions with Disinfectants Avoid using disinfectants that contain quaternary ammonium salts, as these may precipitate hyaluronic acid, affecting...

Innovating future life. Healvisco® Portfólio www.bioceramed.com Hyaluronic Acid Therapy

Healvisco One® is a highly purified hyaluronic acid gel, specifically developed for viscosupplementation therapy with a single injection, intended for the treatment of conditions affecting synovial joints. Thanks to its high viscosity and hyaluronic acid with an ideal molecular weight (4.5), it improves synovial fluid lubrication and shock absorption, effectively reducing pain and restoring joint mobility. In addition, its unique properties help reduce inflammation through the activation of CD44 receptors, promoting a robust and prolonged biological response.

Main Features of Healvisco® One 2.5% High Molecular Weight Contains 120 mg of sodium hyaluronate in 4.8 ml, with a molecular weight of 1800–3200 kDa, ensuring effective joint lubrication. Viscosity Range With a viscosity range of 350–650 PA·s, Healvisco One® provides superior lubrication and shock absorption, promoting joint health. Clinical Efficacy Clinical studies show a significant reduction in pain and stiffness, improving patient mobility and overall joint function. Duration of Effect The therapeutic benefits of Healvisco One® last up to six months after a single injection, offering prolon

Healvisco® 2.2 is a highly purified hyaluronic acid (HA) gel developed for the treatment of osteoarthritis and other degenerative conditions in synovial joints. It is specifically formulated for three intra-articular injections, aiming to relieve the symptoms of osteoarthritis (OA). Administering three doses may deliver more than double the amount of hyaluronic acid compared to other similar formulations.

Main Features of Healvisco® 2.2% Composition Contains 44 mg of hyaluronic acid in 2 ml, with a molecular weight between 1200 and 1400 kDa, ensuring effective joint lubrication. Viscosity Range Viscosity between 200–380 PA·s, crucial for providing optimized lubrication and efficient shock absorption in joint treatment. Therapeutic Regimen Recommended as a triple intra-articular therapy, weekly or at specific intervals, to effectively relieve pain and improve joint function. Post-Arthroscopic Efficacy The formulation is particularly beneficial after arthroscopic procedures, supporting recovery and...

Healvisco® Mini Healvisco® Mini is indicated for the treatment of osteoarthritis and other degenerative conditions. Meticulously designed to ensure precision and efficacy, it is particularly suitable for small joints, such as facets, metatarsophalangeal, carpometacarpal, temporomandibular, interphalangeal joints, and the ankle. The product effectively contributes to recovery of mobility and pain relief, prc lubrication and shock absorption in thr joints.

Main features of Healvisco® Mini Targeted Treatment – Small Joints Specifically for small joints. Effectively improves mobility and reduces pain in areas such as the temporomandibular joints and ankle. Composition Contains 16 mg of sodium hyaluronate per ml of gel, with a molecular weight of 1200–1400 kDa, ensuring high quality and efficacy. Viscosity Range Viscosity of 60–100 PA·s, Healvisco Mini® is ideal for small joints, providing optimized lubrication and shock absorption. Clinical Efficacy Effective pain reduction after just 1 to 3 intra-articular injections, offering a fast response for patients....

Healvisco® Tendon Healvisco® Tendon is designed for the treatment of tendinopathies and enthesopathies. The molecular weight of the hyaluronic acid selected specifically for Healvisco Tendon ensures a robust biological response and an anticatabolic effect when administered via peritendinous or intratendinous injections. Treatment with Healvisco Tendon results in rapid and clinically significant pain reduction, improved tendon functionality, and accelerates the patient's return to physical activity.

Main Features of Healvisco® Tendon Healvisco® Tendon Specifically designed to effectively treat tendinopathies and enthesopathies, facilitating a faster recovery process. Composition Each 2 ml syringe contains 32 mg of HA with a molecular weight of 1400–1600 kDa, providing excellent therapeutic effects. Viscosity Range With a viscosity of 70–200 PA·s, Healvisco® Tendon effectively reduces friction and promotes healing in tendon injuries. Cellular Binding Its long-chain HA ensures strong binding to CD44 receptors, enhancing cellular response and anticatabolic effects. Mechanism of Action Acts by...