Biphasic osteoconductive scaffold that favors bone regeneration Neobone ® is a biphasic resorbable bone substitute. Intended for bony voids that are not intrinsic to the stability of the bone structure. Neobone® is used in Orthopaedic and Traumatology. e material is synthetic, does not contain animal or human tissues or derivates. Developed under the rigorous standards and quality control of the medical device industry. Bioceramed is a ISO 13485 certified company, and our products are CE marked. Absence of immune infectious response or disease transmission. CHARACTERISTICS Neobone ® composed of biphasic mixture 75% Hydroxyapatite and 25% β-Tricalcium Phosphate, showing a good compromise between the mechanical properties and the resorption rate. Neobone® is a porous scaffold with interconnected porosity, enhancing the vascularization and colonization of the graft by the bone cells. Neobone® is available in various granules, blocks and wedges sizes. OTHER BENEFITS Neobone® is radiopaque, which allow the observation of the healing process. e use of synthetic grafts avoids the autograft procedure thus minimizing the complications and morbidities associated and reducing the surgery time. e material and biological characteristics of osteoindctive calcium phosphate ceramics. Regenerative biomaterials, v.5, n.1, p. 43-59, 2017. 2. BOULER, Jean-Michel et al. Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response. Acta biomaterialia, v.53, p. 1-12, 2017. 3. EBRAHIMI, Mehdi; BOTELHO, Michael G.; DOROZHKIN, Sergey V. Biphasic calcium phosphates bioceramics (HA/TCP): Concept, physicochemical properties and the impact of standardization of study protocols in biomaterials research. Materials Science and Engineering: C, v. 71, p. 1293-1312, 2017. bioceramed biomaterials for tissue regeneration

Fractures, gaps or skeletal system defects(femur, tibia, humerus, ulna, fibula, calcaneous, hand, among others). Non-unions Knee osteotomy Filling of bone curettage Neobone® block 10x10x5 mm - - 1 uni. Blocks 10x10x5 mm 1 uni. Neobone® Irregular granules 0,5-1 mm - 1g Neobone® block 10x10x5 mm - - 3 uni. Blocks 10x10x5 mm 3 uni. Neobone® Irregular granules 0,5-1 mm - 2g Neobone® block 10x10x5 mm - - 5 uni. Blocks 10x10x5 mm 5 uni. Neobone® Irregular granules 1-2 mm - 0,5g Neobone® block 10x30x5 mm - - 1 uni. Blocks 10x30x5 mm 1 uni. Neobone® Irregular granules 1-2 mm - 1g Neobone® block 10x30x5...