AUTOMATED DISPENSING SYSTEM FOR FLUORESCENCE IN SITU HYBRIDIZATION FEATURES AND BENEFITS • Automated Cell Dropping Automated Probe/DAPI Dispensing Integrated Hybridization Improve Metaphase Spread Quality Perform Up To 8 Assays On One Slide Reduce Probe/Assay Cost Remove The Need For Rubber Cement 12 Slide Processing Capability The dropping process has remained a highly manual technique for years, leaving an automation void between harvesters and microscopes. CellWriter now completes the continuum, by automating the dropping process to deliver quality spread interphase and metaphase nuclei for analysis. The CellWriter 120 is a robotic workstation that produces slides for both Karyotyping and FISH. nanoliter dispenser (BioJetTM) with exquisite temperature and Image 1: Metaphase cell labeled with X Centromere (green) and Y Centromere (red) probes. Cells couterstained with DAPI plus Vectashield. Image taken with the Zeiss Axio Imager. M1 using the 100x Oil objective. humidity control, we have developed a highly efficient system that produces quality slides. BioDot further simplifies the workflow by introducing a new, patented slide technology. CellWriter SlidesTM enable multiplexed FISH assays and eliminate the need for rubber cement when preparing for hybridization (a step that is both messy and time consuming). Image 2 & 3 : Male metaphase and interphase cells labeled with X Centromere (green) and Y Centromere (red) probes. Cells couterstained with DAPI plus Vectashield. Image taken with the Zeiss Axio Imager. M1 using the 20x objective. The CellWriter 120 processes 12 slides per batch.

Dispense Volume Dynamic Range Dispense Volume Precision Humidity Control Slide Temperature Fume Filtering • Specialty-blended Filter Media [i.e. Acid Gas, Mercury, Aldehyde, Ammonia] Power Requirement Vacuum Requirement Dispense Channels per System (Sample/Probe) • CellWriter 120 STS with Automated Dispense Channels per System (FIX) • LI MS Integration Barcode Scanning • Linear (All Standard Formats), 2D (Data Matrix, FISHArray Technology Don't simply automate the workflow. Improve it. BioDot introduces the FISHArray™ technology, enabling labs to perform as many as 8 different FISH assays on...