BIOHIT ColonView® (FIT) quick test For early diagnosis and screening of colorectal cancer Detects bleeding derived from lower GI tract Detection of occult blood in feces is essential in the early diagnosis of colorectal cancer. The BIOHIT ColonView quick test is an immunological lateral flow test which detects hemoglobin and hemoglobin-haptoglobin complex (degraded hemoglobin) from stool. With this combination of two biomarkers, the ColonView test can be used for detecting bleeding originating in the proximal and distal colon. This makes ColonView a superior tool to detect bleeding cancer tumors and their precursors. Testing made easy The stool specimens are collected easily with the stool collection paper and sample applicator stick. To guarantee the best possible accuracy, it is recommend to take samples on 3 consecutive days. 1. Make bowel movement onto the collection paper. • Detects bleeding from proximal and distal lesions • Adenoma & carcinoma: sensitivity 97% and specificity 85% (1) • Hygienic sampling, transportation and analysis • No dietary restrictions before sample collection • Results in 15 min 2. Unscrew the blue end and remove the sample applicator. 3. Collect sample by inserting the stick into the stool specimen. 4. Re-insert applicator stick. and apply drop three drops to the test cassette. The clever design of the ColonView sampling tube eliminates patient-errors and ensures that there will always be the correct sample amount. The sampling tube contains all the necessary reagents and no additional accessories are needed for the analysis. One sample is enough for the testing of both Hb and Hb/Hp complex, and the result is ready in 15 minutes. One sample for dual testing 6. Read after 15 minutes

• Sample: stool • Test principle: immunological detection of Hb and Hb/Hp complex • Kit components: test cassettes, sample collection package (sample collection tube, specimen collection paper, and sample collections instruction) and • Quality control: BIOHIT ColonView® QT Control 1. Vasilyev S, Smirnova E, Popov D et al. Anticancer Res 2015; 35:2873-2880. Not available in the United States. In Japan for research use only. Check availability for other markets. Ordering details: REF Product 602250.02 BIOHIT ColonView® quick test, 30 tests 602390 BIOHIT ColonView® QT Control Contact our team for...