HYPRO­OSS & HYPRO­SORB Innovative Bovine Biomaterials for Implantology, Periodontology and Maxillofacial Surgery Biotech Innovation Pioneers

Letter from the General Manager Dear clinical user, Bioimplon's focus is to develop, manufacture and market unique native bovine products in the cutting edge field of regenerative medicine. Our extensive product offerings cover the fields of bone and tissue regeneration, tissue engineering and wound healing for dental, spinal, orthopaedic and dermatologic applications. They are used by oral and maxillofacial surgeons, periodontists and dental implantologists as well as by orthopaedic and spinal surgeons. Patient safety, ease of use, reliable and predictable treatment results are our first priorities....

Bioimplon - Bovine biomaterials for your needs 1 Hypro-Oss - Bovine bone substitute 2 Hypro-Sorb M Matrix - Guided tissue regeneration 6 Hypro-Sorb M and F Membranes - Guided tissue and bone regeneration 10 Hypro-Sorb R - Haemostatic sponges 14 Hypro-Sorb X and Z - Alveolar ridge preservation and haemostasis 16 Certifications and Copyright 22 © bioimplon 2015

Bovine biomaterials for your needs Bioimplon GmbH is one of the leaders in the development, manufacture, and distribution of innovative regenerative biomaterials for the medical and dental fields. Our product portfolio includes: • Bone substitute material • Membranes for guided bone and tissue regeneration (GBR / GTR) • Collagen matrices for GBR / GTR and haemostasis • Haemostatic sponges and cones Our biomaterials are indicated for use in the following dental fields: Maxillofacial Surgery We continuously invest in research and development and trust in our qualified and specialized employees....

Hypro-Oss® Hypro-Oss® is a natural bovine bone substitute material with incorporated atelocollagen. It is used for the permanent filling or reconstruction of antiseptic bone defects. mPjon iGmbH Hypro-Oss enhanced awacuusmtyp., d™»!jtruaion„b cotimpound Jone deficits Hypro-Oss Properties and advantages Hypro-Oss is produced with our patented atelopeptidation and lyophilization technologies. These result in the following important characteristics: • Native bovine bone graft composite for enhanced new bone formation • Telopeptide-free collagen components; non-immunogenic peptide • Acceleration...

Bovine bone substitute Hypro-Oss grain size: 1.0 - 2.0 mm Hypro-Oss grain size: 0.5 - 1.0 mm Indications in implantology, periodontology and maxillofacial surgery: • • • • • • • • Sinus lift Vertical and horizontal augmentation Intraosseous defects Peri-implant defects Extraction sockets Furcation defects Filling of cysts Periodontal defects Hypro-Oss used together with Hypro-Sorb F. Images courtesy of Dr. Amir Gazmawe DMD Prosthodontist

Hypro-Oss is a natural bovine bone graft. Each granule consists of approximately 70% hydroxyapatite and 30% atelocollagen Type I. It is sterile and safe. Chemical composition: Human bone in comparison to lyophilized bovine bone

Hypro-OssAvailable sizes and volumes Product Name / Description Storage conditions Hypro-Oss must be stored in a dry place at room temperature. Hypro-Oss is not damaged by temperatures from 0°Cto +50°C. It needs to avoid sources of heat and direct sunlight. Hypro-Oss is a sterile medical device class III, ISO and CE certified.

Hypro­Sorb® M Matrix Our multilayer atelocollagen matrix for guided tissue regeneration in periodontology and maxillofacial surgery The Hypro-Sorb® M Matrix is a multilayer tissue matrix of pure, crystalline atelocollagen (telopeptide-free collagen) derived from the bovine Achilles tendon. The Hypro-Sorb M Matrix supports neovascularization and controlled soft tissue integration and is a safe alternative to the patients’ own soft tissue grafting material. In addition, it has an excellent barrier function due to the solid collagen structure and long resorption time of six months. The Hypro-Sorb...

Hypro-Sorb M Matrix Advantages • Consistent availability and safety • No need for autograft harvesting • High patient acceptance • Reliable clinical results • Cost effective Hypro-Sorb M Matrix Properties • Biocompatible pure, crystalline atelocollagen type I - free of antigenic telopeptides (for more information on atelocollagen, see the chapter About atelocollagen) • Multilayer soft tissue structure • Rapid neovascularization and integration • Accelerates soft tissue replacement without the need for autograft harvesting • Complete remodeling into patients’ own tissue Hypro-Sorb M Matrix - 25...

Hypro-Sorb M Matrix Indications • Maxillofacial and periodontal surgery • Treatment of gingival recession • Sinus lifting • Segmental growing of the alveolar tissue • Periim plantitis • Furcation treatment • Vertical and segmental augmentation • Cleft lip and palate 1. Trim the matrix to the size you need using scissors 2. The matrix should overlap the walls of the defect by at least 2-3 mm in order to achieve complete coverage of the bone and thus prevent lateral ingrowth of gingival tissue 3. The defect cavity is then filled loosely with bone substitute material such as...

Composition Natural pure (99.9%), crystalline, multilayer atelocollagen tissue structure of bovine tendon. Storage conditions The Hypro-Sorb M Matrix must be stored in a dry place at room temperature. It is not damaged by temperatures between -25°C to +50°C. It must be protected from direct sunlight and heat. The product is sterile for five years. Hypro-Sorb M is a medical device class III, ISO and CE certified.

Hypro­Sorb® M and F Our natural atelocollagen membranes for guided tissue and bone regeneration in maxillofacial surgery and implantology Hypro-Sorb® M membranes are biphasic, bilayer membranes of pure, crystalline atelocollagen of bovine origin. They come in three different sizes and two convenient thicknesses. The membranes differ with regards to their handling: The 0.8 mm thick Hypro-Sorb M membrane is soft, whereas the 0.3 mm thick Hypro-Sorb M membrane is medium rigid. Due to the special processing of the collagen fibers it is not necessary to soak these membranes with saline or the patient's...