Hypro-Oss
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biOimolon GmbH ' Biotech Innovation Pioneers Leading Biomaterial Innovations for the 21th century

Hypro-Oss Hypro-Oss is a patented lyophilized natural bovine bone graft incorporated with Atelocollagen Type I resulting from 6 years of intensive research and development cooperation between the scientic teams of the companies BIOIMPLON GMBH and HYPRO OTROKOVICE S.R.O.; the teams of both companies include very experienced chemistry engineers under the leadership of engineer Antonin Galatik and medical researchers under the leadership of Dr. Sami Watad, who cooperated very closely with several biomaterial academic institutes and universities in Europe. This continuous, intensive cooperation...

Unique & Smart Concept Our concept for the development of the Hypro-Oss product line was conceived with the idea of an ideal biomaterial in mind, a material with the highest biocompatibility and afnity to the new endogenous bone. In order to accomplish this purpose, we implemented our proprietary atelopeptidation and lyophilization technologies that preserve natural collagen components of bone material within bone structure after modifying the collagen to a non-immunogenic atelocollagen. This preserves the natural crystalline structure of the hydroxyapatite as well as the collagen...

Physicochemical Processing the Power of Atelopeptidation and Lyophilization Atelopeptidation is a term that describes the physicochemical deletion of the immunogenic/antigenic terminal peptide sequence (telopeptide) in a collagen molecule. The resulting modied collagen is called an atelocollagen, a safe non-immunogenic collagen that can be implanted in patients without any adverse reactions. Our patented biological atelopeptidation technology allows us to physicochemically delete the antigenic peptide segment, located at the terminal peptide of collagen molecules within the bone compound,...

Lyophilization Processing Power Many methods have been proposed and used around the world for processing and storing bone tissue for clinical application. Lyophilization is the optimal choice. It is a technique that evaporates water contained in a product by sublimation, i.e. a previously frozen material is placed in a vacuum, which turns the ice to vapor. Moreover, lyophilization provides mainly bovine material with biocompatibility, and it also enables storage at room temperature. The presence of lyophilized collagen with lower humidity inside each granule makes Hypro-Oss bone matrix...

Atelocollagen’s Vital Role in Bone Regeneration Process Atelocollagen Type I is the most appropriate carrier for promoting osteoinductive signal activity. In vitro studies show that collagen is capable of inducing differentiation of mesenchymal osteoprogenitor stem cells into osteoblasts, and that the association of Atelocollagen Type I with a scaffold of natural hydroxyapatite signicantly enhances the proliferation rate of osteoblasts. This important scientic evidence provides the rationale behind the development of HyproOss products’ line. Hypro-Oss atelocollagenated bone graft provides...

In addition to its well-known structural effect on connective tissues, collagen is endowed with the following important properties, which are helpful in tissue reparation processes: a- Hemostasis: Collagen can activate the receptors on cellular membranes of platelets, which are responsible for their aggregation and degradation processes. b- Debridement: Collagen acts chemo-tactically on monocyte/macrophage cell lines from which osteoclasts derive. These cells, through their activity on mineral component reabsorption of both bone tissue and Hypro-Oss biomaterials, activate and collaborate...

Beauty Comes from Within - Collagen too! Clinical routine shows that stability plays an important role during the early stages of implantology treatment. The quicker and more intensive the osseointegration process, the higher the stability of the implant. Hypro-Oss is an incomparably stable, highly puried, and well established HA/collagen bone graft material of bovine origin. It goes further towards satisfying the requirements for increased safety, enhanced new bone formation and integration and better predictability. The material is used for Oral Guided Bone Regeneration (GBR) in the...

Hypro-Oss - Long-Term Success The very good reception of Hypro-Oss is evident in its efcacy. Hydroxyapatite of bovine origin has been successfully used in clinical medicine since 1958. Radiological follow-ups showed consolidation of the defects consistent with the healing phase. Biopsies retrieved from clinical grafts showed that the hydroxyapatite had almost completely been surrounded by bone and that newly formed bone had also been deposited inside the granule pores. The long-term results were also conrmed by clinical applications. Hypro-Oss implantation tests and the results of...

Hypro-Oss - Properties • Natural bovine bone grafting material with incorporated biocompatible collagen • Atelo-collagenated and lyophilized grafting material • Pure bone mineral and pure Collagen Type I composition • Directed integration and enhanced new bone formation • Osteoinductive atelocollagen components • Osteoconductive hydroxyapatite components • No foreign body or inammatory reaction • Hydrophilic, optimal cell adhesion and blood absorption • Native crystalline structure interconnective porosity • Long-term dimensional stability • Safe and sterile • Easy handling Hypro-Oss –...

Hypro-Oss – Sterilization & BSE safety BSE prevention regulations The manufacturer has documents at its disposal conrming that the country has established compulsory notication of BSE and that all slaughtered animals older than 72 months are subject to obligatory examination based on the Notices of the Department of Agriculture no. 287/1999, Coll. of Laws and DOA no. 309/2011, Coll. of Laws. The manufacturer monitors and reacts to current requirements or directives issued by the European Union, including the OIE notice Terrestrial Animal Health Code. Control of animal feeding The country of...