Biosan SIA, Ratsupites iela 7 k-2, Riga, Latvia, LV-1067 E-mail: [email protected], www.biosan.lv Phone:+37167426137 RTS-1C, Personal bioreactor DESCRIPTION RTS-1C is personal bioreactor which utilize patented Reverse-Spin® technology that applies non-invasive, mechanically driven, low energy consumption, innovative type of agitation where cell suspension is mixed by the singleuse falcon bioreactor tube rotation around its axis with a change of direction of rotation motion resulting in highly efficient mixing and oxygenation for aerobic cultivation. Combined with a near-infrared optical system it is possible to register cell growth kinetics non-invasively in real time. Reverse–Spin® mixing principle in 50 ml falcon tubes allows to achieve high kLa (h-1) up to 450 which is essential for efficient aerobic cultivation Individually controlled bioreactor accelerates optimization process Possibility to cultivate microaerophilic and obligate anaerobic microorganisms (not strict anaerobic conditions) Reverse–Spin® mixing principle enables non-invasive biomass measurement in real time Near-infrared optical system makes it possible to register cell growth kinetics Free of charge software for storage, demonstration and analysis of data in real time Compact design with low profile and small footprint for personal application Temperature control for bioprocess applications Active cooling for rapid temperature control, e.g. for temperature fluctuation experiments Task profiling for process automatization Cloud data storage to remotely monitor the process of cultivation while at home or using a mobile phone Software features: Real–Time cell growth logging 3D graphical representation of OD or growth rate over time over unit Pause option Save/Load option Report option: PDF and Excel Connect up to 10 units simultaneously to 1 computer Remote monitoring option (requires internet connection) Cycling/Profiling options User manual calibration possibility for most cells CAT. NUMBER Including TPP TubeSpin® Bioreactor vessels 50ml, 20pcs BS-010160-A04 Typical applications: Fermentation real time growth kinetics Clone candidate screening Protein expression Temperature stress and fluctuation experiments Media screening and optimization Growth characterization Inhibition and toxicity tests Strain quality control

SPECIFICATIONS Measurement range 0–10 OD at 10–20ml volume (0–19 OD λ600 nm equivalent) 0–8 OD at 20–30ml volume (0–15.2 OD λ600 nm equivalent) Measurement precision Light source Measurement periodicity per hour Cultural media volume Temperature setting range Temperature control range Temperature stability Speed control range Max. number of units connected to the software Type of tube for aerobic cultivation 50 ml tube with membrane filter (TubeSpin® Bioreactor 50, TPP®)* Type of tube for anaerobic cultivation 50 ml tube with membrane filter (TubeSpin® Bioreactor 50, TPP®)* * — it is also possible...

50 ml tubes with membrane filter TPP TubeSpin® Bioreactor 50, 20 pcs. 50 ml tubes with membrane filter TPP TubeSpin® Bioreactor 50, 180 pcs.