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RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement

RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement
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RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement - 1

Biosan SIA., Ratsupites 7, build. 2, Riga, LV-1067, Latvia, Phone: +371 674 261 37, Fax: +371 674 281 01, E-mail: marketing@biosan.lv, www.biosan.lv RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement DESCRIPTION RTS-8 plus is a personal bioreactor that utilizes patented Reverse-Spin® technology that applies non-invasive, mechanically driven, low energy consumption, innovative type of agitation where cell suspension is mixed by the single-use falcon bioreactor tube rotation around its axis with a change of direction of rotation motion resulting in highly eﬃcient mixing and oxygenation for aerobic cultivation. Combined with a near-infrared, ﬂuorescence and luminescence measurement systems, it is possible to register cell growth kinetics, pH and O2 non-invasively in real time. For pH and O2, innovative single-use sensor spots are used inside the tubes. Although O2 supply is one of the major issues in the cultivation of aerobic organisms, especially in oxygen limited conditions, adequate methods for real monitoring of dissolved oxygen were missing, and suﬃcient O2 supply was usually assumed. Innovative non-invasive oxygen sensors integrated in falcon tubes now enable online oxygen monitoring and give new insights into metabolic activities. The pH is one of the major issues in the cultivation of cells, yeast or bacteria. Cultivation vessels which are sensor limited are widely applied in academic and industrial bioprocess development. As adequate methods for real monitoring of pH were not available, cumbersome at-line sampling was used lacking high data density and interfering with growth. Noninvasive real time pH measurement provides new insights into metabolic activity and changes in metabolic pathways. FEATURES Parallel cultivation of 8 tube bioreactors enables to save time and resources for bioprocess optimization Individually controlled bioreactor accelerates optimization process Possibility to cultivate microaerophilic and obligate anaerobic microorganisms (not strict anaerobic conditions) Reverse–Spin® mixing principle enables non-invasive biomass measurement in real time Near-infrared optical system makes it possible to register cell growth kinetics Free of charge software for storage, demonstration and analysis of data in real time Compact design with low profile and small footprint for personal application Individual temperature control for bioprocess applications Active cooling for rapid temperature control, e.g. for temperature fluctuation experiments Task profiling for process automatization Cloud data storage to remotely monitor the process of cultivation while at home or using a mobile phone Non-invasive O2 and pH measurement allows for accurate monitoring of metabolic activities CAT. NUMBER Including TPP TubeSpin® Bioreactor vessels 50ml, 20pcs and sterile TPP TubeSpin® Bioreactor vessels, 50ml, with pH and O2 sensors, 10pcs BS-010170-A01 ADVANTAGES OF THE SENSOR SPOTS: They are small Their signal does not depend on the flow rate of the sample They can be physically divided from the measuring system which allows a non-invasive measurement They can be used in disposables Therefore, they are ideally suited for the examination of small sample volumes, for highly parallelized measurements in disposables, and for biotechnological applications SOFTWARE FEATURES Real–Time cell growth logging Real-Time pH and O2 measurement and logging 3D graphical representation of OD or growth rate over time over unit Pause option Save/Load option RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement

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RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement - 2

Report option: PDF and Excel Remote monitoring option (requires internet connection) Cycling/Profiling options User manual calibration possibility for most cells TYPICAL APPLICATIONS Fermentation real time growth kinetics Clone candidate screening Protein expression Temperature stress and fluctuation experiments Media screening and optimization Growth characterization Inhibition and toxicity tests Strain quality control Initial bioprocess optimization studies To fully use RTS-8 plus capabilities, the device must be connected to a PC and RTS-8 plus software. The device cannot be used as a...

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RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement - 3

Nominal operating voltage Power consumption 02 sensor Range Accuracy Drift Temperature range Response time (t90) Storage stability pH sensor Range Accuracy Drift Temperature range Response time (t90) Storage stability RTS-8 Plus, Multi-channel Bioreactor with non-invasive real time cell concentration pH and O2 measurement

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