Technical Summary of SARS-CoV-2 Antibody Testing Parameters

1. Test Types and Targets

The document references several types of tests related to SARS-CoV-2 detection and immune response assessment, including capacitive assays, neutralizing antibody (Ab) tests specific to SARS-CoV-2, and ferritin measurements.

2. Cut-Off Index (COI) Values

COI values are used to interpret test results, with thresholds defined as follows:

• COI < 1: Negative or below threshold
• COI > 1: Positive or above threshold

These thresholds apply across different test categories, including SARS-CoV-2 neutralizing antibodies and ferritin levels.

3. Performance Metrics

The tests demonstrate high performance with the following key parameters:

• Specificity: ≥ 98%
• Sensitivity: ≥ 95%

These metrics indicate a low rate of false positives and false negatives, ensuring reliable detection of SARS-CoV-2 antibodies and related biomarkers.

4. Summary of Key Points

• Capacitive assays and neutralizing antibody tests are used for SARS-CoV-2 immune response evaluation.
• COI thresholds (1.0) are critical for result interpretation.
• Ferritin levels are also measured, possibly as an inflammatory marker.
• High specificity and sensitivity values ensure test reliability.