PAIN - THERMAL ALLODYNIA / HYPERALGESIA BIOSEBIn Vivo Research Instruments AN INNOVATIVE, ACCURATE AND EASY-TO-USE INSTRUMENT FOR YOUR RESEARCH ON ANALGESIA Set the plate to the chosen temperature and wait for the thermometer to display it has been achieved. Place the subject on plate within the enclosure and start the built-in chronometer using the button on the front panel or the foot pedal. The operator stops the chronometer when the animal demonstrates a nociceptive response, such as paw lick, hind paw withdrawal, or jump. Reaction time remains displayed in seconds on the front panel until zeroed. Bioseb designed the CHP as a stand- alone instrument. Its capacity can be augmented by optional software for programming temperature ramps and looping protocols. • Neuropathic pain • Chronic pain • Nerve injury • Mood disorders see out website for more specific applications... INSTRUMENT OVERVIEW Bioseb's Dynamic Cold/Hot Plate Test is an innovative instrument opening new investigation fields for your analgesia research by allowing you to test animal's sensitivity to pain resulting from exposure to heat or cold. Thermal stimulation is a common technique to assess peripheral sensitivity threshold. It is a standard test along with mechanical stimulation for a large spectrum of pain related research and to control for other behavioural assays. Bioseb's Cold Hot Plate is a user-friendly device to measure thermal pain resistance / sensitivity resulting from exposure to heat or cold. An electronic thermostat maintains the temperature within the broad range of -2°C to 55°C (European Ethical guidelines) with a surface temperature uniformity of ±0.2°C, avoiding movements to a more comfortable zone and biased results. For special applications, our extended version (BIO-CHP-ER) allows setups in the range of -5 °C to +65°C. Its sturdy and fast Cooling/Heating system makes it the most reactive, and hence dynamic device on the market. Equipped with transparent enclosure, a front panel digital thermometer that displays the current plate temperature, and a chronometer to count the stimulation duration, it is a perfect stand-alone solution. • Standard CHP works from -2 to 55 °C • Extended CHP works from -5 to 65 °C • Homogeneity all over the plate, at any temperature • Fastest on the market to reach target temperature • Embedded thermometer and timer • Optional red colored transparent cage (BIO-CHP-CAGES-R) • Expandable to thermal preference testing TECHNICAL SPECIFICATIONS Phone: North America +1 727 521 1808 - Europe & other Areas +33 442 344 360 - Email: [email protected]

BIO-CHP: Dynamic Cold/Hot Plate OPTIONAL SOFTWARE: BIO-CHP-RAMP Though it is functional as a stand-alone instrument, the Cold Hot Plate Test Analgesia Meter can also be used with optional software, allowing the user to define temperature «ramps» and «Loops». • Software controls the temperature for generation of a continuous and reproducible ramp or loop • Ramps allow for identification of the precise nociceptive behavior-inducing temperature for each subject • Loop protocol design is useful for subject acclimation • Pre-set temperature limits can be programmed to prevent damage to animal's paws...