Bioseb is the leading manufacturer of research instruments for in-vivo pain study and recognized worldwide for its innovative developments in close collaboration with researchers. North America +1 727 521 1808 • Europe & other Areas +33 442 344 360 envelope [email protected] laptop www.bioseb.com SPECIAL DEVELOPMENTS We are proud of our partnerships with public & private research labs, which enable us to develop innovative instruments tailored to your needs, like the Electronic Von Frey with embedded camera or the Whirlpool bath. To help you achieve 3R compliance, we develop dedicated acquisition & analysis software, limiting operator-induced variability and reducing the number of animals used. Contact us to participate in validations and improvements or develop new tests based on your ideas and needs. MOTOR-CONTROL & COORDINATION Grip strength test A robust device to quantify the muscular strength of rodents. ROTAROD Fully automated for rat, mice and dual species. Optional software available. Automatic Ladder Test Video software for detecting and scoring errors for each paw. SPONTANEOUS & FORCED ACTIVITY Home cage ActiVMeter Recording animals’ activity, rearing and climbing during night and day. Activity Wheels Stand alone or connected to a computer, recording the distance travelled. Treadmills Full range for mice & rats from 1 to 5 lanes - forced exercise training & acute fatigue testing. Whirl-Pool Test Controlled whirpool bath to improve rodent endurance or develop cardiovascular resistance.

NON-EVOKED PAIN & POSTURAL DEFICIT Static Weight Bearing test Measure the weight bearing force for rear paws and display both curves. Dynamic Weight Bearing test Weight bearing force on each paw & other postural parameters on a freely moving rodent. GAIT ANALYSIS KWB: Kinetic Weight Bearing test Detect & record true individual weight bearing forces & all other gait analysis parameters. PAIN - MECHANICAL ALLODYNIA/HYPERALGESIA Video Electronic Von Frey Stimulator with camera: easy targeting & video recording for test analysis. Von Frey Test Platform Complete setup incl. frame and 2 cages, to be...

BEHAVIOR, ANXIETY & DEPRESSION Tail Suspension Test Original design by Porsolt et al. Automated version with up to 6 mice and USB port. Forced Swimming test Automated version combining vibrations and video. Completely operator-independent. Automated Open Field Track the animal in 3 dimensions & detect rearing in all light conditions. Elevated Plus Maze Open and closed sections for study of anxiety, with fully automated software. LEARNING - MEMORY - ATTENTION - ADDICTION Startle & Fear Conditioning Fully automated system based on high sensitivity weight transducers. Shuttle Boxes (Active & Passive)...

SERVICES Our work starts upstream, thanks to our partnerships with research institutes, by developing innovative solutions matching your needs - but our mission also extends downstream by offering you the best support available. Whether you need calibration certificates, or want us to come to your lab to install your equipment, our team is by your side. We provide environmental measurement tools to ensure results quality, and our support force will help you fine-tune both hardware & software use. From concept to support over calibration and installation: your partnership with Bioseb is a longterm...